摘要
目的对比评价医院对围手术期抗菌药物预防性应用进行综合干预的效果。方法分别抽取医院2012年第一季(A组)和第四季(B组)归档手术病例(均含Ⅰ类和Ⅱ类切口手术),比较综合干预前后医院围手术期抗菌药物预防性应用情况,并结合制定的围手术期预防性应用抗菌药物评价标准予以分析。结果综合干预后该院围手术期预防性应用抗菌药物合理性得到提高。其中围手术期预防性抗菌药物使用率和无指征预防用药率由91.14%和50.38%,分别下降至干预后的49.56%和11.89%,干预前后差异存在统计学意义(P<0.01)。同时在首剂给药时机、预防用药疗程、抗菌药物品种选择合理率方面也有大幅度改善,分别由干预前的22.25%、16.11%、23.27%提高至干预后的75.77%、82.38%和53.74%,差异均有统计学意义(P<0.01)。结论医院对围手术期预防性应用抗菌药物实施综合性干预措施行之有效,可规范围手术期预防性应用抗菌药物,促进临床合理用药。
Objective To evaluate the effect of comprehensive intervention on prophylactic use of antibiotics inpatients during perioperative period. Methods Extract surgical cases （ include Ⅰand Ⅱincision） during the first （ group of A） and fourth（ group of B） quarters of 2012 in our hospital, and evaluate the reasonableness of prophylactic antimicrobial agents in perioperative period. Results Rationality prophylactic use of antimicrobial agents during perioperative period was improved. The utilization rates of antimicrobial and no indications medication dropped from 91. 14% and 50. 38% to 49.56% and 11.89% after the intervention, the differences were statistically significant （P 〈 0.01 ）. Rationalitys of timing of the first dosage, course of treatment and drug selection were 22.25% ,16.11% and 23.27%, respectively. After the intervention,they increased to 75.77%, 82. 38% and 53. 74%. The differences were also significant （ P 〈 0. 01 ）. Conclusion Interventions to applications of antibiotics during perioperative period were effective and the rationality had been improved significantly, which can standardize the clinical use of antibiotics during perioperative period.
出处
《中华全科医学》
2015年第10期1630-1631,1652,共3页
Chinese Journal of General Practice
关键词
围手术期
抗菌药物
预防性应用
管理
Peroperative period
Antimicrobial drugs
Prophylactic use
Administration
