摘要
目的探讨肝硬化严重程度与血清甲状腺素、总胆酸、癌抗原125(CA125)水平的相关性。方法收集2011年6月至2013年6月在磁县人民医院内五科就诊的肝硬化患者98例,根据ChildPugh评分分为轻度组(40例),中度组(32例),重度组(26例),另选同期健康体检者28例设为健康对照组(28例),比较分析4组血清甲状腺素、总胆酸、CA125水平。结果轻度组患者血清总甲状腺素(TT4)、总三碘甲状腺原氨酸(TT3)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平分别为(81.6±14.6)nmol/L、(1.6±0.3)nmol/L、(2.6±1.3)pmol/L、(9.8±3.5)pmol/L,中度组患者血清TT4、TT3、FT3、FT4水平分别为(71.3±12.4)nmol/L、(1.0±0.2)nmol/L、(1.7±0.8)pmol/L、(7.1±3.3)pmol/L,重度组分别为(52.7±11.5)nmol/L、(0.8±0.1)nmol/L、(1.2±0.4)pmol/L、(5.1±2.7)pmol/L,均显著低于对照组[(120.9±18.3)nmol/L、(1.9±0.4)nmol/L、(6.7±2.3)pmol/L、(16.5±5.9)pmol/L],中度组低于轻度组,重度组低于中度组(P<0.05);轻度组、中度组、重度组血清总胆酸水平分别为(30.8±10.3)、(41.2±12.3)、(56.2±14.0)μmol/L,均明显高于对照组[(6.1±1.9)μmol/L](P<0.05),中度组明显高于轻度组,重度组显著高于中度组(P<0.05);轻度组、中度组、重度组肝硬化患者血清CA125水平分别为(2.3±0.5)、(4.3±1.1)、(23.9±9.1)k U/L,显著高于对照组(1.0±0.5)k U/L(P<0.05);中度组明显高于轻度组,重度组明显高于中度组(P<0.05)。肝硬化严重程度与血清TT4、TT3、FT3、FT4呈负相关(r=-0.548,-0.472,-0.615,-0.523,均P=0.000),而与总胆酸、CA125水平呈正相关(r=0.671,0.714,均P=0.000)。结论血清甲状腺素、总胆酸及CA125可作为肝硬化严重程度Child-Pugh分级法的辅助指标,有助于准确评估病情和预后。
Objective To investigate the correlation between the severity of liver cirrhosis and serum thyroxine,total bile acid,CA125.Methods A total of 98 patients with liver cirrhosis treated in gastroenter-ology department of Cixian People′s Hospital from Jun.2011 to Jun.2013 were collected, and they were divided into mild group（n=40）,moderate group（n=32）,severe group（n =26） according to Child-Pugh score,while another 28 healthy persons who for physical examination during the same period were inlcuded as healthy control group（n=28）,then the serum thyroxine,total bile acid,CA125 level of the three groups were compared and analyzed.Results The serum TT4 ,TT3 ,FT3 ,FT4 levels of patients in the mild group ,moder-ate group and severe group were respectively[（81.6 ±14.6） nmol/L,（1.6 ±0.3） nmol/L,（2.6 ±1.3） pmol/L,（9.8 ±3.5） pmol/L;（71.3 ±12.4） nmol/L,（1.0 ±0.2） nmol/L,（1.7 ±0.8） pmol/L,（7.1 ± 3.3） pmol/L;（52.7 ±11.5） nmol/L,（0.8 ±0.1） nmol/L,（1.2 ±0.4） pmol/L,（5.1 ±2.7） pmol/L], which were significantly lower than those in the control group[（120.9 ±18.3） nmol/L,（1.9 ±0.4） nmol/L, （6.7 ±2.3） pmol/L,（16.5 ±5.9） pmol/L],those in the moderate group were lower than those in the mild group,those in the severe group were lower than those in the moderate group （P〈0.05）;the serum total bile acid levels in the mild group,moderate group and severe group were （30.8 ±10.3）,（41.2 ±12.3）, （56.2 ±14.0） μmol/L respectively,which were significantly higher than those in the control group[（6.1 ± 1.9）μmol/L]（P〈0.05）,that in the moderate group was significantly higher than that in the mild group, that in the severe group was significantly higher than that in the moderate group （ P〈0.05 ）;the serum CA125 in the mild group,moderate group and severe group were （2.3±0.5）,（4.3 ±1.1）,（23.9 ±9.1） kU/L respectively,which were significantly higher than that in the control group（1.0 ±0.5） kU/L（P〈0.
出处
《医学综述》
2015年第15期2850-2852,共3页
Medical Recapitulate
