摘要
目的观察清肺化痰中药雾化吸入辅助治疗呼吸机相关性肺炎(VAP)的临床疗效及安全性。方法选取符合标准的VAP患者80例,随机分为治疗组与对照组,各40例,2组均给予沐舒坦(盐酸氨溴索)常规雾化吸入及泰能(亚胺培南/西司他丁钠)抗生素常规治疗,治疗组在常规治疗的基础上加用清肺化痰中药雾化吸入辅助治疗,对比2组治疗前后体温、中医证候评分、白细胞计数(WBC)、APACHE评分及血清降钙素原(PCT)水平变化。结果治疗组总有效率及治疗后体温、中医证候评分、白细胞计数、APACHE评分改善均显著优于对照组(P<0.05);治疗组治疗后血清PCT水平显著低于对照组(P<0.05)。结论西医常规治疗联合清肺化痰中药雾化吸入辅助治疗VAP,可改善临床症状,降低PCT水平。
Objective To observe the clinical efficacy of the aerosol inhalation of the traditional Chinese medicine that can clear lung and phlegm in the adjuvant therapy of ventilator-associated pneumonia（ VAP） and its safety. Methods A total of 80 VAP patients who met the criteria were included in the study and randomized into the treatment group and the control group. The patients in the two groups were given routine aerosol inhalation of Mucosolvan（ ambroxol hydrochloride） and the antibiotic of Tienam（ imipenem cilastatin sodium）. Based on the routine treatment,the patients in the treatment group were treated with the aerosol inhalation of the traditional Chinese medicine that can clear lung and phlegm. The changes of body temperature,TCM syndrome score,WBC,APACHE score and PCT level before and after treatment in the two groups were compared. Results The total effective rate,the body temperature after treatment,TCM syndrome score,WBC,and APACHE score in the treatment group were significantly superior to those in the control group（ P〈0. 05）. The serum PCT level after treatment in the treatment group was significantly lower than that in the control group（ P〈0. 05）. Conclusion The western medicine in combined with the aerosol inhalation of the traditional Chinese medicine that can clear lung and phlegm in the adjuvant therapy of VAP has a definite efficacy and can significantly improve the patients＇ clinical symptoms; therefore,it deserves to be widely recommended in the clinic.
出处
《长春中医药大学学报》
2015年第4期757-758,共2页
Journal of Changchun University of Chinese Medicine
基金
张家口市科学技术成果项目(219122534)
