摘要
目的评价中医综合方案治疗脑卒中后轻度认知障碍远期临床有效性。方法纳入200例脑卒中后轻度认知功能障碍患者,通过随机方案分为干预组104例,对照组96例。对照组给予非药物干预,干预组在对照组非药物干预基础上口服中药复方苁蓉益智胶囊,每次4粒,每日3次,同时配合中医特色疗法。2组疗程均为180天。干预期结束90天后分别用蒙特利尔认知评估量表(北京版)(Mo CA)、日常生活活动能力量表(ADL)评定患者认知功能、日常生活能力,并观察患者中医核心症状改善情况。结果 2组患者Mo CA总分较入组时均有改善,差异有统计学意义(P<0.01);且干预组同期Mo CA总分改善情况优于对照组,差异均有统计学意义(P<0.01)。Mo CA各亚项中,干预组抽象、延迟回忆的改善情况优于对照组(P<0.05,P<0.01)。2组患者ADL总分较入组时均有改善,差异均有统计学意义(P<0.05,P<0.01),但2组间差异无统计学意义。干预组"言谈不知首尾,时作时止""转盼遗忘""语后便忘,思量不能""神思不聚""反应迟钝"等5条中医核心症状较入组时均有改善,差异有统计学意义(P<0.05,P<0.01)。结论中医综合干预方案治疗脑卒中后轻度认知障碍患者,具有较好的远期疗效,可提高患者认知功能水平,改善患者中医核心症状。
Objective To evaluate the long-term clinical efficacy of TCM comprehensive intervention on mild post-stroke cognitive impairment. Methods 200 cases of patients with mild post-stroke cognitive impairment were included and randomized into the intervention group of 104 and the control group of 96. The control group was given non-medicinal intervention,and the intervention group was treated with Compound Congrong Yizhi Capsule with 4 capsules each time and 3 times a day apart from the non-medicinal intervention as in the control group in combination with some TCM featured therapies. The treatment for both groups lasted for 180 days. After 90 days from the end of intervention,Montreal Cognitive Assessment（ Beijing edition）（ Mo CA） and Activities of Daily Living（ ADL） were used to evaluate the cognitive ability,activities of daily living and the improvement of core symptoms observed in patients. Results The Mo CA total scores of two groups were both improved compared with that in inclusion and the difference was statistically significant（ P〈0. 01）; and the Mo CA total scores of Intervention group was more improved than that of the control group,the difference was statistically significant（ P〈0. 01）,especially in abstract and delayed memory. The ADL total scores of two groups were improved,the difference was statistically significant（ P〈0. 05,P〈0. 01）,but the difference wasn ＇t statistical significant between the two groups. Five core symptoms of the intervention group were improved a lot than that in inclusion,including speaking with incomplete meaning,forgetting things quickly,poor memory after speaking,distractibility,and retardation, the differences were statistically significant（ P〈0. 05 or P〈0. 01）. Conclusion TCM comprehensive intervention for the patients with PSCIND has a good long-term curative effect,as it may increase the patient＇cognitive function and improve TCM core symptoms.
出处
《北京中医药》
2015年第7期507-512,共6页
Beijing Journal of Traditional Chinese Medicine
基金
2010年中医药行业科研专项(201007002)
2014年中医药行业科技专项(201407001)
关键词
脑卒中
轻度认知障碍
中医干预
认知功能
日常生理能力
远期疗效
cerebral infarction
mild cognitive impairment
TCM comprehensive intervention
cognitive function
activity of daily living
long-term curative efficacy
