摘要
目的 分析妊娠期急性脂肪肝（AFLP）的临床特征及其终止妊娠时间对母儿预后产生的影响。方法 收集我院2011年10月至2013年10月期间诊治的妊娠期急性脂肪肝患者120例作为研究对象,按照不同的诊断及分娩时间将患者分为A组、B组和C组,A组为确诊后1 d以内终止妊娠,共计40例,B组为确诊后1～2 d终止妊娠,共计30例,C组为确诊后2 d超过2 d终止妊娠组,共计50例,回顾性分析患者的临床资料。结果 研究结果显示,B、C两组急性肾功能衰竭发生率、24 h尿蛋白超过3 g的比率明显高于A组,数据比较差异具有统计学意义（P〈0.01）;C组弥散性血管内凝血发生率、孕产妇病死率、新生儿窒息率及围生儿病死率明显高于A组,数据比较差异具有统计学意义（P〈0.05）;三组急性脂肪肝孕产妇阴道分娩率、剖宫产分娩率比较具有明显差异（P〈0.05）。结论 妊娠期急性脂肪肝一旦确诊应及时的处理,在确诊后48 h内终止妊娠可减少母婴预后的影响。
Objective To analyze the clinical features of acute fatty liver （markers） during pregnancy and its termination time mother to son prognostic impact. Methods Collected from October 2011 to October 2013, during the treatment period, 120 patients with acute fatty liver of pregnancy as the research object, according to the patients with different diagnosis and delivery time will be divided into group A and group B and group C, group A to diagnose the pregnancy is terminated within one day, A total of 40 cases of group B is confirmed after 1 d or 2 d termination of pregnancy, A total of 30 cases, group C for two days more than two days after diagnosis to terminate pregnancy group, A total of 50 cases, the clinical data of patients were retrospectively analyzed. Results The results showed that B and C in the two groups the incidence of acute renal failure, 24 hours urine protein more than 3 g was significantly higher than that of group A, data comparison differences statistically significant （P〈0.01）; Group C diffuse intravascular coagulation rate, maternal mortality, neonatal asphyxia rate and perinatal mortality is significantly higher than group A, data comparison differences statistically significant （P〈0.05）; Three groups of acute fatty liver of matemal vaginal births, cesarean births has the obvious difference （P〈 0.05）. Conclusion Pregnancy once diagnosed acute fatty liver should be dealt with in a timely manner, in the pregnancy is terminated within 48 hours after diagnosis can reduce the influence of maternal and infant prognosis.
出处
《中国医药指南》
2015年第22期41-41,44,共2页
Guide of China Medicine
关键词
妊娠期急性脂肪肝
临床特征
终止妊娠
母儿预后
影响
Pregnancy with acute fatty liver
Clinical features
Termination of pregnancy
Mother son prognosis
Impact
