摘要
目的评价兔眼全层巩膜咬切术、小梁切除术和植管引流手术三种青光眼滤过手术模型的优缺点。方法健康新西兰白兔72只96眼,分别接受全层巩膜咬切术(30只,30眼)、小梁切除术(18只,18眼)和植管引流手术(24只,48眼),观察三种滤过手术术中虹膜周边切除后是否出血,术中是否玻璃体脱出,术后第1天眼压、滤过泡、前房炎症反应和前房积血情况。结果全层巩膜咬切术、小梁切除术中虹膜周边切除后出血发生率分别为90.0%、50.0%,差异有统计学意义(χ2=65.280,P<0.05)。全层巩膜咬切术、小梁切除术中玻璃体脱出率分别为100.0%、27.8%,差异有统计学意义(χ2=80.412,P<0.05)。三种手术模型术前和术后第1天眼压分别为(13.48±1.73)mm Hg(1 k Pa=7.5 mm Hg)和(10.58±3.12)mm Hg(全层巩膜咬切术),(10.03±1.03)mm Hg和(8.71±4.65)mm Hg(小梁切除术),(11.94±1.19)mm Hg和(6.96±3.25)mm Hg(植管手术);各滤过模型术后第1天降眼压幅度之间差异有统计学意义(F=5.940,P<0.05)。全层巩膜咬切术、小梁切除术和植管引流手术后第1天滤过泡直径在3 mm以上分别为28眼、18眼、48眼,差异有统计学意义(χ2=11.460,P=0.012);前房炎症反应在1级以上分别为30眼、18眼、29眼,差异有统计学意义(χ2=46.604,P=0.000);前房积血分别为11眼、3眼、1眼,差异有统计学意义(χ2=16.820,P=0.000)。结论植管手术模型术中并发症少,术后滤过泡形成好,眼压控制低,前房炎症反应轻,前房出血发生率低,是三种青光眼滤过手术模型中最为理想的模型。
Objective To compare the complications of three types of rabbit glaucoma filtration surgery model, which include full-thickness sclerectomy, trabeculectomy and tube drainage surgery. Methods Seventy-two healthy New Zealand white rabbits were performed the full-thickness sclerectomy （ 30 cases, 30 eyes）, trabeculectomy （18 cases, 18 eyes） and tube drainage surgery （24 cases,48 eyes） ,respectively. The incidence of hyphema,vitreous prolapsed during operation of the three models were observed,and the intraocular pressure, filter blebs appearance and anterior chamber in- flammatory reaction on the first day after operation were also observed. Results The incidence of hyphema in hill-thickness scleretomy and trabeculectomy were 90.0% and 50.0% , there was statistical difference （X2 = 65. 280 ,P 〈 0.05 ）. The incidence of vit- reous prolapse in hill-thickness scleretomy and trabeculectomy were 100. 0% and 27. 8% during operation, there was statistical difference （X2 = 80. 412, P 〈 0.05 ）. The preoperative intraocular pressure before full-thickness scleretomy, trabeculectomy and tube drainage surgery were （ 13.48 ± 1.73 ） mmHg（ 1 kPa = 7.5 mmHg）, （ 10.03 ± 1.03 ） mmHg and （ 11.94 ±1.19 ） mmHg, respectively, and the intraocular pressure of the first postoperative day were （ 10.58 ± 3.12） mmHg, （ 8.7 1± 4.55 ） mmHg and （ 6.96 ± 3.25 ） mmHg, respectively, there was statistical difference in the reduced intraocular pressure range among three types of filtration surgery model （F = 5. 940 ,P 〈 0.05 ）. The range of filter blebs wider than 3 mm on the first postoperative day in the full-thickness scleretomy, trabeculectomy and tube drainage surgery group were respectively 28 eyes, 18 eyes and 48 eyes,the difference was statistical significant （X2 =11. 460,P = 0. 012 ）. Anterior chamber inflammatory reaction classified above level I （ anterior chamber flare without exudate） on the first postoperative day in the full-thickness scleretomy,trabeculectomy and tu
出处
《眼科新进展》
CAS
北大核心
2015年第8期731-734,共4页
Recent Advances in Ophthalmology
关键词
青光眼
动物模型
滤过手术
兔
glaucoma
animal model
filtration surgery
rabbit
