摘要
目的：评估谷氨酰胺联合肠道微生态制剂对食管癌患者术后体液免疫的影响。方法将行食管癌手术的90例患者随机分为实验组（45例）和对照组（45例），术后当日均开始给予肠内营养，其中实验组术后在常规肠内营养的基础上于第1～5天加用丙氨酰谷氨酰胺注射液及金双歧片，对照组仅给予常规肠内营养。于术前，术后第2天、第7天分别检测患者的体液免疫指标（IgA、IgG、IgM）。结果实验组 IgM、IgG 水平在术后第7天分别为（14.89±1.77）g／L、（2.30±0.63）g／L，明显高于对照组的（11.41±2.11）g／L、（2.18±0.77）g／L，差异均有统计学意义（P ＜0.05）。结论丙胺酰谷氨酰胺及肠道微生态制剂联合肠内营养支持可以改善食管癌患者术后体液免疫状况。
Objective To evaluate the effect of alanyl -glutamine and microecological preparations on postoperative humoral immune function of patients with esophageal carcinoma.Methods 90 patients with esophageal carcinoma were randomly divided into the study group and the control group.Both groups received standard enteralnutrition,and patients in study group were smi-ultaneously added with alanylglutamine solution （20 g per day）and intestine microecologic agents （golden bifido）after the oper-ation,but the control group did not receive those.The IgA,IgG and IgMwere measured on preoperative,the 2nd and 7th postoper-ative day.Results The levels of IgM,IgG were （14.89 ±1.77）g/L,（2.30 ±0.63）g/L in the study group on the 7th postop-erative day,which were significantly higher than those in control group （11.41 ±2.11 ）g/L,（2.18 ±0.77）g/L （All P 〈0.05）.Conclusion Alanyl -glutamine and microecological preparations can improve postoperative intestinal mucosal barrieral function and humoral immune function in patients with esophageal carcinoma.
出处
《河南医学研究》
CAS
2015年第3期31-33,共3页
Henan Medical Research
关键词
食管癌
谷氨酰胺
微生态制剂
体液免疫
esophageal carcinoma
alanyl -glutamine
microecological preparations
humoral immune
