摘要
目的比较不同治疗措施治疗带状疱疹神经痛的止痛效果,优化带状疱疹神经痛治疗方案。方法通过军卫一号病案管理系统,收集2009年1月1日-2013年12月20日带状疱疹住院患者资料,按治疗措施不同分为5组。A组:盐酸伐昔洛韦胶囊+盐酸多塞平片;B组:盐酸伐昔洛韦胶囊;C组:盐酸伐昔洛韦胶囊+盐酸奈福泮片+盐酸多塞平片;D组:盐酸伐昔洛韦胶囊+盐酸奈福泮片;E组:盐酸伐昔洛韦胶囊+非甾体类抗炎药(包括尼美舒利胶囊、布洛芬胶囊)。统计每组患者性别、年龄、发病至入院时间、治疗后疼痛消失时间,统计分析不同治疗方案患者疼痛消失时间的差异。结果共收集病案资料898份,符合上述5组要求者336例,A、B、C、D、E组分别为72、86、66、60、52例,治疗后疼痛消失时间分别为(5.94±2.54)、(8.60±3.09)、(5.77±1.85)、(5.80±1.96)、(6.86±2.18)d;治疗后疼痛消失时间B组与其余4组差异均有统计学意义(P<0.05);E组与A、C、D组间差异有统计学意义(P<0.05),A组、C组与D组间差异无统计学意义(P>0.05)。结论以上治疗方案均对带状疱疹神经痛治疗有效。盐酸奈福泮片和盐酸多塞平片治疗效果优于尼美舒利胶囊和布洛芬胶囊。盐酸奈福泮片和盐酸多塞平片疗效无差别,且两者联用不增加疗效。
Objective To compare the analgesic effect of different treatment for herpes zoster neuralgia,and optimize herpetic neuralgia treatment.Methods We collected hospital inpatient data with herpes zoster by the First Military Medical Case Management System between January 1 st,2009 and December 20 th,2013.All the patients were divided into five groups according to different treatments.Patients in group A accepted valaciclovir capsules and doxepin hydrochloride tablets; patients in group B accepted valaciclovir capsules; patients in group C accepted valaciclovir capsule,nefopam hydrochloride tablets and doxepin hydrochloride tablets; patients in group D accepted valaciclovir capsules and nefopam hydrochloride tablets; patients in group E accepted valaciclovir capsules and non-steroidal anti-inflammatory drugs（including nimesulide capsules and ibuprofen sustained-release capsules）.We collected such statistic data as sex,age,time of onset,time of pain disappearing after treatment.Then,we analyzed the difference among the groups on the time of pain disappearing.Results There were 336 cases compliant with the standard in all the 898 cases of medical record data.The number of the patients was 72,86,66,60 and 52; while the pain disappearing time after treatment was（ 5.94 ± 2.54）,（ 8.60 ± 3.09）,（ 5.77 ± 1.85）,（ 5.80 ± 1.96） and（ 6.86 ± 2.18） days,respectively in group A,B,C,D and E.Pain disappearing time after treatment of group B was significantly different from groups A,C,D,and E（ P 〈0.05）; group E was significantly different from groups A,C,and D（ P 〈0.05）; there was no significant difference between group A and groups C and D,and between group C and D（ P〉0.05）.Conclusions The combination of nefopam hydrochloride tablets,doxepin hydrochloride tablets,nimesulide capsules,and ibuprofen sustained-release capsules is effective in the treatment of herpes zoster neuralgia.The use of nefopam hydrochloride tablets with doxepin hydrochloride tablets is more effective than the combinati
出处
《华西医学》
CAS
2015年第7期1243-1245,共3页
West China Medical Journal
