摘要
目的评估连续性血液净化技术(CBP)治疗重型流感的临床疗效。方法将重型流感患者分为两组,观察组早期进行CBP治疗,对照组未进行CBP治疗,通过监测患者生命体征、急性生理与慢性健康(APACHE II)评分、序贯器官功能衰竭(SOFA)评分、氧合指数(Pa O2/Fi O2)、C反应蛋白(CRP)、平台压(Pplat)、病毒清除情况等指标。比较两组患者的炎症反应、肺损伤程度及死亡率。结果观察组及对照组治疗前的APACHEⅡ评分、SOFA评分、Pa O2/Fi O2、CRP和Pplat比较差异均无统计学意义(P>0.05)。经治疗后观察组患者的APACHEⅡ评分为12.9±7.5,SOFA评分为4.3±3.6,CRP为(46.3±29.9)mg/L,Pplat为(15.1±4.9)cm H2O,死亡率3.84%,而观察组的Pa O2/Fi O2为299.0±35.3,明显高于对照组的276.2±33.9,两组差异有统计学意义(P<0.05)。观察组中患者继发细菌性肺炎及呼吸系统细菌感染的发生率低于对照组,两组差异有统计学意义(P<0.05)。结论早期应用连续性血液净化技术可安全有效应用于重型流感患者,因此它可以考虑作为治疗重型流感的一个重要手段。
Objective To evaluate the effect of early continuous blood purification（CBP）on patients with severeinfluenza. Methods The patients with severe influenza were divided into the observation group treated with early CBPtherapy and the control group without CBP therapy,the extent of inflammatory reaction,the severity of lung lesions and themortality of the patients in two groups were compared through monitoring the vital signs,APACHE Ⅱ score,SOFA score,oxygenation index,C-reactive protein,plateau pressure and virus clearance of the patients. Results No statistical significantdifferences in the APACHEⅡ score,SOFA score,oxygenation index,C-reactive protein,plateau pressure and mortality incases of two groups before treatment were noticed（P〉0.05）.The APACHEⅡscore（12.9±7.5）,SOFA score（4.3±3.6）,C-reactive protein（46.3±29.9mg/L）,Pplat（15.1±4.9cm H2O）,mortality（3.84%）of the patients in the observation group afterthe treatment were significantly lower than that of the control group,while the oxygenation index of patients in observationgroup（299.0±35.3）was significantly higher than that of the control group（276.2±33.9）,the difference of two groups wasstatistically significant（P〈0.05）. The incidence of secondary bacterial pneumonia and respiratory bacterial infection in thepatients of the observation group was lower than that of the control group exhibiting statistically significance（P〈0.05）.Conclusions Early continuous blood purification is safe and effective for treatment of the patients with severe influenza,so itcan be considered as an important treatment for severe influenza.
出处
《中国热带医学》
CAS
2015年第7期872-874,889,共4页
China Tropical Medicine
关键词
重型流感
连续性血液净化技术
全身炎症反应综合征
连续性静脉血液透析滤过
Severe influenza
Continuous blood purification
Systemic inflammatory response syndrome
Continuous veno-venous hemodiafiltration
