摘要
目的观察依达拉奉联合磷酸肌酸钠对颅内动脉瘤术后脑血管痉挛的临床效果。方法选取颅内动脉瘤破裂出血术后患者60例,随机分为观察组和对照组各30例。对照组采用尼莫地平等常规治疗,观察组在对照组治疗的基础上联合应用依达拉奉及磷酸肌酸钠治疗。治疗前和治疗后2周,经颅多谱勒超声(transcraninal Doppler sonography,TCD)分别测定大脑中动脉的血流速度评价血管痉挛程度,同时采用美国国立卫生院神经功能缺损评分(National Institutes of Health Stroke Scale,NIHSS)对比2组的临床疗效,并比较2组不良反应的发生情况。结果治疗2周后,2组血管痉挛情况均较治疗前明显改善(P<0.01)。观察组大脑中动脉平均血流速度较对照组显著降低(P<0.01),NIHSS较对照组明显降低(P<0.01)。2组脑梗死发生率、病死率及不良反应发生率比较差异均无统计学意义(P>0.05)。结论依达拉奉联合磷酸肌酸钠治疗颅内动脉瘤术后脑血管痉挛引起的脑缺血效果确切,能明显改善患者预后。
Objective To explore the clinical effect and safety of edaravone combined with phosphocreatine in the treatment of cerebral vasospasm from intracranial aneurysm.MethodsSixty patients with intracranial rupture hemorrhage after operation were randomly divided into two groups,the control group was treated with conventional therapy which involved nimodipine injection,vinpocetine,etc.,and the treatment group was treated with edaravone combined with phosphocreatine based on the conventional therapy.The clinical efficacy was compared after two weeks＇ treatment.The blood velocity of middle cerebral artery（MCA）,incidence rate of cerebral infarction and death rate were observed and compared between two groups.Besides,National Institutes of Health Stroke Scale（NIHSS）was used to evaluate the degree of nervous functional defects.Finally,the incidences of side effects were compared between two groups.Results After two weeks＇ treatment,the cerebral vasospasm of two groups were improved as compared with before treatment,the mean blood flow velocity of MCA in treatment group was statistically lower than that of control group（P〈0.01）,the NIHSS in treatment group was significantly lower than that of control group（P〈0.01）.There were no significant difference in cerebral infarction incidence,mortality and adverse reactions between two groups（P〈0.05）.Conclusion Edaravone combined with phosphocreatine was remarkably effective in the prevention of cerebral vasospasm after intracranial aneurysm surgery,and the therapy can improve the prognosis of patients.
出处
《河北医科大学学报》
CAS
2015年第7期755-758,共4页
Journal of Hebei Medical University
基金
河北省医学科学研究重点课题计划(20130240)
河北省中医药管理局中医药类科研计划课题(2013019)
