摘要
近年来,天然产物姜黄素因其显著的抗肿瘤等多种生物活性引起广泛关注。然而姜黄素水溶性差、化学结构不稳定、生物利用度低,限制了其在临床上的进一步应用。用小分子或大分子载体对姜黄素的酚羟基进行修饰制备得到的姜黄素前药能较好地解决姜黄素上述的缺点,也是改善姜黄素成药性的有效策略。综述了近年来国内外姜黄素前药的研究进展。
In recent years,curcumin,a natura1 product,has been drawing attention from researchers for its many kinds of significant bioactivities. such as antitumor activity. However,its clinica1 utility is limited due to a number of undesirable difficulties,such as its low aqueous solubility,instability and low bioavailability. Through conjugated the phenolic hydroxyl group of curcumin with low or high molecular weight carriers,various prodrugs of curcumin have been studied and developed to overcome its disadvantages. The development of prodrugs of curcumin was an effective method to improve the druggability of curcumin. In this paper. the research progresses in the prodrugs of curcumin in recent years were reviewed.
出处
《海峡药学》
2015年第6期3-8,共6页
Strait Pharmaceutical Journal
关键词
姜黄素
前药
抗肿瘤
抗氧化性
抗菌
抗炎
Curcumin
Prodrugs
Antitumor
Antiodant
Antibiosis
Anti-inflammatory
