摘要
目的研究两种不同HAART方案对HIV／AIDS患者脂代谢的影响。方法分析河南地区124例HIV／AIDS患者HAART后随访96周脂代谢的变化和这些变化与两种不同HAART方案的关系。结果HAART后24周随访，血脂异常率从56．9％下降至40％，三酰甘油（TG）从1．57mmo//L下降至1．29mmo/lL，高密度脂蛋白（HDL-C）从1．19mmol/L上升至1．66mmol/L；TG恢复到基线水平，96周上升至1．66mmol/L；总胆固醇持续升高，低密度脂蛋白（LDL—C）小幅波动而HDL—C水平下降。48周随访，血脂异常率升高至64％。96周随访，血脂异常率再次下降至57．1％。多变量分析，与使用包含d4T方案的患者相比使用包含AZT方案患者24周TG下降的水平更低（-0．64V8．-0．03mmol/L），96周上升的水平较低。结论长期使用包含核苷类反转录酶抑制剂的HAART方案对HIV／AIDS患者脂代谢产生不利的影响，包含d4T的方案影响更显著。
Objective To study the effect of two different HAART regimens on lipid metabolism in patients with HIV/AIDS. Methods Among 124 HIV-infected adults in Henan, the long-term lipid changes over 96 weeks following HAART initiation and their associations with two different first-line HAART agents were analyzed. Results In 24 weeks of HAART, the prevalence of dyslipidemia decreased from 56. 9% to 40% , triglycerde（TG） decreased from 1.57 mmol/L to 1.29 mmol/L, and HDL cholesterol（HDL-C） increased from 1.19 mmol/L to 1.66 mmol/L. After 24 weeks, TG returned to its baseline level and increased to 1.66 mmol/L at 96 weeks. Total cholesterol（TC） continued to increase, and LDL cholesterol（LDL-C） fluctuated, while HDL-C level decreased. The prevalence of dyslipidemia increased to 64% after 48 - week follow-up, and then it decreased to 57.1% after 96 - week follow-up. According to muhivatiate analysis, patients with AZT-eontaining regimens had a greater reduction in TG levels at 24 weeks（ -0. 64 versus -0. 03 mmoL/L） , and a lower increase at 96 weeks compared to pa- tients with d4T-containing regimens （ -0. 26 versus 0. 24 mmol/L, P 〈 0.05 ）. Conclusions Long-term NRTIs-containing HAART regimens has effect on lipid metabolism in HIV/AIDS patients, especially d4T-containing regimens.
出处
《中国实用医刊》
2015年第15期7-11,共5页
Chinese Journal of Practical Medicine
基金
郑州市科技发展计划课题（112PPTSF303-3）
