摘要
目的 探讨18F-FDG PET/CT对临床怀疑宫颈癌局部复发和（或）远处转移患者的诊断价值.方法 回顾性分析95例宫颈癌治疗后患者的18F-FDG PET/CT检查资料,采用视觉分析和半定量方法（SUVmax）分析病灶特点,最终诊断以活组织病理检查、诊断性治疗及影像学随访结果为准,采用Kappa一致性检验进行分析.结果 共有54例患者18 F-FDG PET/CT检查发现局部复发和（或）远处转移病灶,其中局部复发24例,远处转移30例;18F-FDG PET/CT诊断肿瘤复发与转移的灵敏度、特异性和准确性分别为98.1％（52/53）、95.2％ （40/42）和96.8％ （92/95）,阳性预测值与阴性预测值分别为96.3％ （52/54）和97.6％（40/41）.18F-FDG PET/CT检查结果与病理及临床随访结果一致性良好（Kappa=0.936,P＜0.05）.结论 18F-FDG PET/CT对临床可疑宫颈癌复发的诊断具有较高的灵敏度和特异性,有助于局部复发和（或）远处转移病灶的检测,对临床进一步的诊疗具有指导作用.
Objective To evaluate the value of whole body 18F-FDG PET/CT in the detection of recurrence/metastasis of cervical cancer.Methods A retrospective study was performed on 95 patients with cervical cancer who underwent 18F-FDG PET/CT after treatment.The lesion characteristics on 18F-FDG PET/CT were assessed visually and semi-quantitatively.A final diagnosis was confirmed by histopathology,diagnostic treatment and clinical follow-up imaging.The data were analyzed by Kappa test.Results 18 F-FDG PET/CT was positive in 54 patients,including 24 with local recurrence and 30 with distant metastases.The sensitivity,specificity and accuracy of 18F-FDG PET/CT for the detection of recurrence/metastasis of cervical cancer were 98.1% （52/53）,95.2% （40/42） and 96.8% （92/95）,respectively.The positive predictive and negative predictive value were 96.3% （52/54） and 97.6% （40/41）,respectively.18F-FDG PET/CT showed concordant results with pathological/clinical follow-up findings （Kappa =0.936,P〈0.05）.Conclusion 18F-FDG PET/CT is a sensitive and specific modality for the detection of recurrence/metastasis of cervical cancer and might be useful for further treatment plan.
出处
《中华核医学与分子影像杂志》
北大核心
2015年第3期164-167,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
