摘要
目的探讨血清鳞状细胞癌抗原(SCC-Ag)在宫颈鳞状细胞癌中的变化及诊断意义。方法选取40例行根治性手术治疗的宫颈鳞状细胞浸润癌患者为宫颈癌组,40例子宫肌瘤患者为非宫颈癌组。酶联免疫吸附法(ELISA)检测宫颈癌组(术前、术后)与非宫颈癌组患者血清SCC-Ag水平。计算SCC-Ag对宫颈鳞状细胞癌诊断的灵敏度与特异度;分析SCCAg水平与宫颈鳞状细胞癌临床病理特征的关系。结果宫颈癌组SCC-Ag阳性率显著高于非宫颈癌组(P<0.01);SCC-Ag对宫颈鳞状细胞癌诊断的灵敏度为86.2%,特异度为63.6%;宫颈癌组血清SCC-Ag水平高于非宫颈癌组(P<0.01);血清SCC-Ag水平与临床分期、浸润深度、盆腔淋巴结转移存在明显相关性(P<0.01),与组织分化程度无显著相关性(P>0.05);行根治性手术治疗后,宫颈癌组血清SCC-Ag水平明显低于手术前(P<0.01)。结论 SCC-Ag为宫颈鳞状细胞癌特异肿瘤标志物,可作为辅助诊断指标;对于宫颈鳞状细胞癌的早期诊断、临床分期、治疗效果评价等方面具有重要的临床意义。
Objective To explore the changes and diagnostic significance of serum squamous cell carcinoma antigen （SCC-Ag） in cervical squamous cell carcinoma. Methods Forty patients with cervical squamous cell invasive carcinoma were given radical surgery and they were considered as cervical carcinoma group, while another 40 patients with hysteromyoma were considered as non-cervical carcinoma group. The level of SCC-Ag in serum was detected by enzyme-linked immunosorbent assay （ELISA）. The sensitivity and specificity of SCC-Ag to the diagnosis of cervical squamous cell carcinoma were calculated. The relationship between SCC-Ag level and clinical pathological characteristics of cervical squamous cell carcinoma was analyzed. Results The positive SCC-Ag rate in the cervical carcinoma group was significantly higher than that in the non-cervical carcinoma group （P 〈 0.01）. The sensitivity and specificity of SCC-Ag for the diagnosis of cervical squamous cell carcinoma were 86.2 % and 63.6 % respectively. Serum SCC-Ag level in the cervical carcinoma group was markedly higher than that in the non-cervical carcinoma group （P 〈 0.01 ）, which was obviously associated with clinical stages , infiltration depth and pelvic lymph node metastases （P 〈 0.01 ）, but had no conspicuous correlation with tissue differentiation degree （P 〉 0.05）. After the radical surgery, serum SCC-Ag level in the cervical carcinoma group was significantly lower than that before treatment （P 〈 0.01）. Conclusion SCC-Ag, a specific tumor marker of cervical squamous cell carcinoma, can be used as an auxiliary diagnostic index, and it is of great importance in various aspects of cervical squamous cell carcinoma like early diagnosis, clinical stages and evaluation on therapeutic effects.
出处
《实用临床医药杂志》
CAS
2015年第13期56-58,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11520568)
关键词
鳞状细胞癌抗原
宫颈鳞状细胞癌
诊断
serum squamous cell carcinoma antigen
cervical squamous cell carcinoma
diagnosis
