摘要
目的:评价持续滴注氟尿嘧啶为基础的FOLFOX或FOLFIRI联合方案在结直肠癌化疗中心脏毒性的发生情况和临床表现。方法:对接受至少一周期以上FOLFOX或FOLFIRI方案化疗的结直肠癌患者,观察和记录氟尿嘧啶相关的心脏毒性。结果:82例患者进入本研究,10例(12.2%)患者出现了心脏事件,1例心力衰竭,1例室性心动过速,1例心肌梗死,其余7例出现心绞痛;所有患者经停药或舌下含服硝酸甘油等处理后好转。结论:持续滴注氟尿嘧啶为基础的FOLFOX或FOLFIRI结直肠癌化疗方案有一定的心脏毒性,对一些致死性的心脏毒性应高度重视。
Objective： To observe the incidence and clinical characteristics of cardiotoxicity associated with continuous infusional fluorouracil-based chemotherapy regimens FOLFOX or FOLFIRI in the treatment of colorectal cancer. Methods： To collect the cardiotoxicity data associated with fluorouracil in the patients with colorectal cancer,who received one cycle of FOLFOX or FOLFIRI or more. Results： Eighty-two patients entered this study. Ten patients（ 12. 2%） developed cardiac events： Cardiac failure（ n = 1）,ventricular tachycardia（ n = 1）,myocardia infraction（ n = 1）,angina（ n = 7）. All patients recovered by stopping fluorouracil,glycerol trinitrate sublingually. Conclusion：There are considerable cardiotoxicity in the continuous infusional fluorouracil-based chemotherapy regimens FOLFOX or FOLFIRI for colorectal cancer.
出处
《现代肿瘤医学》
CAS
2015年第15期2161-2163,共3页
Journal of Modern Oncology
关键词
氟尿嘧啶
心脏毒性
结直肠癌
fluorouracil
cardiotoxicity
colorectal cancer
