摘要
①目的观察血脂康预防急性心肌梗死冠脉支架置入术后冠脉再狭窄疗效及安全性。②方法将249例急性心肌梗死患者随机分为A组136例及B组113例,均行急诊冠状动脉支架置入术。术前A组给予血脂康胶囊0.6g口服,2次/d,B组给予阿托伐他汀片20mg口服,1次/d。术后A组坚持服用血脂康胶囊0.6g,2次/d,B组服用阿托伐他汀片20mg,1/晚。平均随访15个月,术后6～9个月复查冠脉造影。观察术前、术后6个月总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高敏C一反应蛋白（hs-CRP）水平,观察支架再狭窄发生率、主要不良心脏事件（MACE）发生率等。③结果随访15个月,两组LDL-C水平均明显下降,下降水平比较无显著性差异（P〉0.05）;MACE发生率及支架内再狭窄发生率比较无显著性差异（P均〉0.05）。术前及术后6个月的血清TC水平、血清LDL-C水平、血清hs-CRP水平,两组间比较无显著性差异（P〉0.05）。支架内再狭窄发生率、靶血管再次血运重建及MACE发生率两组间比较均为无显著性差异（P〉0.05）。④结论血脂康与其他药物比较预防急性心肌梗死支架置入术后再狭窄效果安全有效,价格低廉,患者依从性好。
Objective To evaluate effect of Xuezhikang and atorvastatin in patients with acute ST segment elevation myocardial infarction after acute percutaneous coronaryintervention（ PCI）. Methods 249 acute ST segment elevation myocardial infarction patients were selected and were divided according to their diferent medications after operation into 2 groups： group A of 136 patients received Xuezhikang 0. 6g and group B of 113 patients received atorvastatin 20 mg,once at bed-time every day. Before PCI,6 months after PCI,the patients changes of serum total cholesterol（ TC）,low-density lipoprotein cholesterol（ LDL-C）,and high sensitivity C-reactive protein（ hs-CRP） were examined,and coronary arteriography（ CAG） was also conducted 6-9months after PCI. The serum TC levels 6 months after PC1 The levels of TC TG,HDL-C,LDL-C. In-stent restenosi major cardiac event during hospital were observed. Results There were no significant differences（ P〈0. 05） in the serum TC levels before PC1 and 6 months after PC1、The serum LDL-C levels before PC1 and6 months after PC1,The serum hs-CRP level before PCI and one mongth after PC1（ P 0. 05）. After 6th month CAG re-examination showed that there were also no significant differences with in-stent restenosi and MACE between group A and B（ P 0. 05）. Conclusion Xuezhikang can reduce in-stent restenosi after acute percutaneous coronary intervention（ PCI） safety and effectively.
出处
《河北联合大学学报（医学版）》
2015年第4期22-24,共3页
Journal of North China Coal Medical College
基金
河北省中药管理局科学技术研究计划课题(编号:2209223)
关键词
血脂康
急性心肌梗死
急诊支架置入术
治疗依从性
再狭窄
Xuezhikang.Acute myocardial infarction.Acute percutaneous coronary intervention
（PCI）.Treatment compliance.In-stent restenosi
