摘要
Monte Carlo方法常用于质子束剂量模拟以优化质子束临床治疗,合适的物理模型选择关系到Monte Carlo模拟结果的可靠性及模拟效率。本工作选取9个可用于质子模拟的Geant4物理模型,计算比较了质子束在多种介质中的剂量及次级粒子产额。结果表明:标准电磁物理模型、低能电磁Penelope模型和Livermore模型虽在模拟质子整体剂量分布上可接受,但在微观上缺失重粒子生成。参数化驱动模型LHEP的模拟时间最短,但与QGSP相同,均不能产生复杂重离子。QGSP_BIC_EMY模型较其他模型明显低估Bragg峰-入口剂量比和绝对剂量。QGSP_BERT模型、QGSP_BIC模型和FTFP_BERT模型较适合放疗质子束模拟。
The Monte Carlo method is usually used to simulate the feature of the external radiotherapy of proton beam to optimize the clinical therapy scenario.The selection of a suitable physical model is very critical to ensure the correction and the efficiency of the simulation.This work studied nine Geant4 physical models,which are often used in the simulation of radiotherapy of proton beam with energy of 60-250 MeV.The dosagefeatures and the microcosmic secondary yields in different materials were compared.The result shows that,although the standard EM,the low energy Penelope model and the low energy Livermore model can output the right dose distribution,they can＇t simulate the baryon yields.The parametrization driven model LHEP and the Quark gluon stringpre-compound model both can＇t simulate the complex ion transportation.Thus the above five models are not enough for the research calculation in the radiation protection and the radiation damage.The QGSP_BIC_EMY model in Geant4 hadron therapy example is very bad for underestimating the dose ratio of Bragg peak to entrance and absolute dose.The QGSP_BERT model,QGSP_BIC model and FTFP_BERT model are suitable for the radiotherapy proton beam with energy of 60-250 MeV.
出处
《原子能科学技术》
EI
CAS
CSCD
北大核心
2015年第7期1290-1297,共8页
Atomic Energy Science and Technology
基金
中国科学院战略性先导科技专项资助项目(XDA03040000)
合肥工业大学科学发展研究基金资助项目(2013HGXJ0193
J2014HGXJ0093)
合肥工业大学自主创新项目资助(2012HGZY0007)
关键词
物理模型
质子放疗
微观产额
剂量特征量
physical model
proton radiotherapy
microscopic yield
dosage characteristic
