摘要
目的 观察BSD 2000相控阵聚焦热疗联合化疗对耐药性卵巢上皮癌患者恶性腹腔积液的疗效.方法 36例耐药性卵巢上皮癌恶性腹腔积液患者按抽签法随机分为治疗组和对照组各18例,其中治疗组采用BSD 2000相控阵聚焦热疗＋GT方案（吉西他滨1 000 mg/m2静脉滴注,第1、8天;紫杉醇80 mg/m2腹腔注射,第1、8天）化疗;对照组单独采用GT方案化疗.28 d为1个周期,2个周期后评价疗效、患者不良反应、Karnofsky评分、中位生存时间.结果 治疗组有效率（RR）高于对照组[55.6％（10/18）比22.2％（4/18）,P＜0.05],疾病控制率（DCR）亦高于对照组,但差异无统计学意义（P＞0.05）.两组不良反应类似,无Ⅲ～Ⅳ度不良反应发生.治疗组Karnofsky评分改善率高于对照组,差异无统计学意义（P＞0.05）.两组患者中位生存时间、生存率比较差异均无统计学意义（均P＞ 0.05）.结论 BSD 2000相控阵聚焦热疗联合化疗可有效控制耐药性卵巢上皮癌患者恶性腹腔积液,改善患者生命质量,不良反应轻微.
Objective To observe the effect of BSD 2000 deep thermotherapy plus chemotherapy in treatment of malignant seroperitoneum of advanced epithelial ovarian cancer patients with drug resistance.Methods 36 advanced epithelial ovarian cancer patients with malignant seroperitoneum for drug resistance were randomly divided into two groups,trial group （18 cases） and control group （18 cases）.Cases in trial group were treated with BSD 2000 deep thermotherapy plus GT regimen （gemcitabine 1 000 mg/m2 iv d1,d8,taxinol 80 mg/m2 ip d1,d8.28 days for a cycle）,while control group with GT regimen alone.Effect,survival time （median） toxicity and Karnofsky score were evaluated after 2 cycles.Results Response rate （RR） was strongly higher in trial group compared with control group [55.6 % （10/18） vs 22.2 % （4/18）,P 〈 0.05],the same to disease control rate （DCR）,but there was not significant difference between two groups （P 〉 0.05）.The improvement rate of Karnofsky score in trial group was higher than that in control group,which had no significance （P 〉 0.05）.The toxicity were similar in both groups,which had no stage 3 to 4 side-effect.The differences of survival time （median） and survival rate had no statistical significance between two groups （P 〉 0.05）.Conclusion It is useful to eliminate seroperitoneum,improve quality of life and decrease the toxicity for the regimen of BSD 2000 deep thermotherapy plus chemotherapy in treatment of malignant seroperitoneum of advanced epithelial ovarian cancer patients with drug resistance.
出处
《肿瘤研究与临床》
CAS
2015年第6期409-412,共4页
Cancer Research and Clinic
关键词
卵巢肿瘤
高温
诱发
药物疗法
腹腔积液
恶性
抗药性
肿瘤
Ovarian neoplasms
Hyperthermia,induction
Drug therapy
Seroperitoneum,malignant
Drug resistance,neoplasm
