摘要
去乙酰化酶1（sirtuin 1，SIRT1）是去乙酰化酶家族的重要一员，在恶性肿瘤、胚胎发育等病理生理学进程中发挥重要作用。本研究发现过表达SIRT1可加快人胰腺β细胞CRL-1837细胞的DNA合成、抑制细胞的衰老。免疫共沉淀证实SIRT1可以与p53结合，并改变p53的磷酸化水平。
Histone deacetylase 1 （ sirtuin 1, SIRT1 ） is an important member of deacetylase family, and plays an important role in the process of malignant tumor and embryonic development. In this article it was found that overexpression of SIRT1 could accelerate the DNA synthesis in human pancreatic beta cell CRL-1837 and inhibit cell senescence. SIRT1 also could bind to p53 as detected by co-immunoprecipitation and could change the phosphorylation level of p53.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2015年第7期621-622,共2页
Chinese Journal of Endocrinology and Metabolism
