摘要
目的建立宿迁地区健康新生儿甲状腺功能正常参考值。方法入组健康新生儿500名，抽取72h足跟血测定足跟血TSH。入组200名健康新生儿，出生后14d抽取静脉血，检测血清TT3、TT4、TSH、FT3、FT4。同期选取健康成人120名，检测血清TT3、TT4、TSH、FT3、FT4。结果本地区健康新生儿72h足跟血TSH参考范围为0．46～6．59mIU／L，14d血清TT3、TT4、TSH、FT3、FT4参考范围分别为1．10～2．62nmol／L、81．10—158．28nmol／L、0．83—6．39mIU／L、3．76～6．66pmol／L、10．67—22．27pmol／L。与成年人相比较，TSH差别无统计学意义，TT3、TT4、TSH、FT3、FT4差异有统计学意义。结论建立健康新生儿甲状腺功能参考范围值有助于了解新生儿出生后的甲状腺功能水平，根据新生儿72h足跟血的TSH参考值．建议下调初筛先天性甲状腺功能减退症的切点，以减少其临床漏诊率。
Objective To establish thyrotropin （TSH） and thyroid hormones reference ranges during the neonatal period for the healthy term newborns in Suqian. Methods Blood samples from a heel-prick were collected from 500 healthy newborns 72 hours after birth to determine the level of TSH. 200 healthy newborns were chosen to determine the levels of serum TSH and thyroid hormones on the 14th day of life, and then compared with the results from 120 healthy adults. Results The reference range of TSH at 72 hours after birth was 0.46-6.59 mIU/L. The reference ranges of TT3 , TT4 , TSH, FT3 , FT4 on the 14th day of life were 1.10-2.62 nmol/L, 81.10-158.28 nmol/L, 0.83- 6.39 mIU/L, 3.76-6.66 pmoL/L, and 10.67-22.27 pmol/L, respectively. There was no significant difference in the interval of TSH between newborns and adluts, whereas there were significant difference in the intervals of TT3 , TT4 , TSH, FT3 and FT4 between the two groups. Conclusions The establishment of TSH and thyroid hormone reference ranges during the neonatal period for the heahhy term newborns could improve our understanding of the thyroid function during the neonatal period for the healthy term newborns, and our data suggests lowing the initiatory screening cut-off point of congential hypothyroidism.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2015年第7期577-580,共4页
Chinese Journal of Endocrinology and Metabolism
