摘要
目的探讨静脉应用增强免疫力药物对重症腺病毒肺炎(SAP)患儿疗效的影响。方法选取2009年4月至2014年5月收治的SAP患儿168例,随机分为两组,各84例。对照组患儿采用常规治疗,观察组患儿则在此基础上静脉滴注静脉用丙种球蛋白(IVIG)辅助治疗。结果平均发热时间和平均住院时间观察组分别为(5.17±2.58)d和(11.17±5.11)d,对照组分别为(6.78±4.02)d和(12.71±5.75)d,两组比较,差异有统计学意义(t=2.281,2.181,P<0.05);两组使用呼吸机的患儿共21例,观察组11例的平均使用时间为(4.58±1.39)d,对照组10例的平均使用时间为(5.96±3.39)d,两组比较,差异有统计学意义(t=1.992,P=0.047);观察组发生并发症68例,而对照组均发生了并发症,其中肺不张、胸腔积液、心肌炎、中毒性脑病、腹泻病观察组的发生率均明显小于对照组;观察组显效率为22.62%,明显高于对照组的10.71%(χ2=7.872,P=0.002),对照组的无效率明显高于观察组(χ2=4.421,P=0.037)。结论静脉用丙种球蛋白对SAP患儿辅助治疗能减少某些并发症的发生,提高疗效及预后,缩短住院时间、呼吸机使用时间及持续发热时间。
Objective To investigate the curative effect of intravenous immune- enhancing drug on the severe adenovirus pneumonia（ SAP） in children. Methods 168 children cases of SAP in the hospital from April 2009 to May 2014 were selected and randomly divided into the observation group and control group,84 cases in each group. The control group adopted the traditional routine therapy mode,while on this basis the observation group was given the intravenous immune- enhancing drug immunoglobulin（ IG）. Results The average fever time and average length of hospital stay were（ 5. 17 ± 2. 58） d and（ 11. 17 ± 5. 11） d in the observation group and（ 6. 78 ± 4. 02） d and（ 12. 71 ± 5. 75） d in the control group,the differences between the two groups were statistically significant（ t =2. 281,2. 181,P〈0. 05）. 21 cases（ 25. 00%） in the two groups used the breathing machine,including 11 cases in the observation group with the average use time of（ 4. 58 ＋ 1. 39） d and 10 cases in the control group with the average use time of（ 5. 96 ＋ 3. 39） d,the differences between the two groups showed statistical significance（ t = 1. 992,P = 0. 047）; 68 cases in the observation group appeared complications,while all the cases in the control group suffered from complications,in which the occurrence rates of atelectasis,pleural effusion,myocarditis,toxic encephalopathy and diarrhea in the observation group were significantly lower than those in the control group;the effective rate in the observation group was 22. 62%,which was significantly higher than 10. 71% in the control group（ χ^2 = 7. 872,P = 0. 002）,and the ineffective rate in the control group was significantly higher than that in the observation group（ χ^2 = 4. 421,P = 0. 037）. Conclusion The assisted therapy of intravenous immune globulin in the treatment of children SAP can reduce the occurrence of some complications,improve the curative effect and prognosis,shorten the hospitalization time,breathing machine using time and persiste
出处
《中国药业》
CAS
2015年第14期15-16,共2页
China Pharmaceuticals
基金
国家医学教育发展中心课题
课题号2012-04-11-181
关键词
重症腺病毒肺炎
静脉用丙种球蛋白
静脉滴注
儿童
severe adenovirus pneumonia
intravenous immune globulin
intravenous drip
children
