摘要
缺血性脑卒中是全世界疾病中致残或致死的主要原因。研究发现基质金属蛋白酶-2(MMP-2)与基质金属蛋白酶-9(MMP-9)在缺血性脑损伤中发挥了重要的作用,其参与了血脑屏障的破坏、脑水肿及出血性转化等过程,因此抑制MMP-2、MMP-9成为治疗的关键。针刺早期介入治疗能够有效地抑制MMP-2、MMP-9,且具有安全、操作简便、经济等优点,是治疗脑缺血损伤的一种新途径。故本研究将MMP-2、MMP-9与脑缺血的关系以及针刺的治疗作用做以综述。
Ischemic stroke is the leading cause of disability or death all over the world.The study finds that matrix metalloproteinase-2 （ MMP-2 ） and matrix metalloproteinase-9 （ MMP-9 ） play important roles in is-chemic brain injury.They involve in the destruction of the blood brain barrier, brain edema and hemorrhagic transformation process.Therefore, it is the key to inhibiting the activities of MMP-2 and MMP-9.The early intervention of acupuncture can inhibit the activities of MMP-2 and MMP-9 effectively, and it is safe and easy to operate.It is also economical.It may be a new way for the treatment of cerebral ischemia injury.The relationship between MMP-2 and MMP-9 and cerebral ischemia and the therapeutic effect of acupuncture are reviewed as follows.
出处
《针灸临床杂志》
2015年第6期84-87,共4页
Journal of Clinical Acupuncture and Moxibustion
基金
江苏省自然科学基金面上项目
编号:BK20131458
