摘要
目的：应用米非司酮配伍米索前列醇催经止孕,探讨米索前列醇选用不同剂量及不同给药途径对临床效果的影响。方法：根据纳入及排除标准,2008年7月至2009年7月间100例停经≤37天的妇女被随机分为两组,对照组（50例）：第1天晨空腹服米非司酮50 mg,8～12小时后再服25mg,第2天按照第l天同样方法服用,首次服米非司酮36～48小时后口服米索前列醇600μg;观察组（50例）：第1天顿服米非司酮150 mg,服药36～48小时后舌下含服米索前列醇400μg,比较两组治疗结局及药物副反应情况。结果：尿HCG阳性的妇女,对照组完全流产40例,失败5例;观察组完全流产37例,失败6例,两组比较差异无统计学意义（χ2=0.16,P〉0.05）。尿HCG阴性的妇女,对照组中有4例,观察组中有7例月经来潮,两组均达到了较好的催经效果。57例（对照组31例,观察组26例）患者有恶心、呕吐、头晕、乏力、头痛和乳胀等副反应,两组比较差异无统计学意义（χ2=1.02,P〉0.05）。服药后对照组及观察组阴道流血时间分别为7.10±1.62天和7.00±2.50天,两组比较差异无统计学意义（t=-0.24,P〉0.05）。结论：减少米索前列醇给药剂量及使用舌下含化的方法和常规药物流产相比,催经止孕效果一致,且不增加副反应。
Objective： To explore clinical effects for induced menstruation and terminating pregnancy by mifepristone combined with different dosage and administrating routes of misoprostol. M ethods： In 2008 July to 2009 July,100 women with menopause≤37 days were randomly divided into two groups. In the control group（ 50 cases）,the women were given 50 mg of mifepriftone and 25 mg 8- 12 hours later orally on the first day. The schedule on the second day was as the same as above followed by 600 μg of misoprostol 36 ～ 48 hours after oral mifepriftone. In the observation group（ 50 cases）,the women were given a dose of 150 mg of mifepristone orally followed by 400 μg of misoprostol sublingually 36 ～ 48 hours after oral mifepriftone. The treatment outcome and the drug side effect were compared between the two groups. Results： Among the women positive for urine HCG,40 had completed abortions and 5 failures in the control group; 37 had completed abortions and 6 failures in the observation group. The difference was not statistically significant（ χ2= 0. 16,P〈0. 05）. Four of five women in the control group and seven in the observation group with negative urine HCG got success for induced menstruation.Adverse reactions： 57 cases（ 31 cases in the control group and 26 cases in the observation group） experienced nausea,vomiting,dizziness,weakness,headache and breast distention. The difference was not significant between the two groups（ χ2= 1. 02,P〈0. 05）. The duration of vaginal bleeding were 7. 10 ± 1. 62 days and 7. 00 ±2. 50 days in the control and observation group respectively,the difference was not statistically insignificant（ t =- 0. 24,P〈0. 05）. Conclusions： The induced menstruation and abortion efficacy and adverse reactions are similar to routine medical abortion when misoprostol is given by reduced dosing and sublingually.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2015年第6期463-466,共4页
Journal of Practical Obstetrics and Gynecology
基金
国家科技部支撑项目(编号:2006BAI03B10)
关键词
药物流产
药物催经
米非司酮
米索前列醇
Medical abortion
Induced menstruation
Mifepristone
Misoprostol
