摘要
目的评估米非司酮配伍米索前列醇用于催经的临床效果和不良反应。方法月经延期1周内的80例妇女,给米非司酮150mg口服,48小时后复诊,阴道内放置米索前列醇400μg,观察阴道出血、不良反应、阴道是否有排出物等。结果80例中血清人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)阳性51例(51/80,63.75%)为妊娠组,其中45例(45/51,88.24%)完全流产;2例(2/51,3.92%)出血时间超过10天,行清宫术,刮出组织送病理检查证实为蜕膜组织;4例(4/51,7.84%)无出血,10天后B超诊断为宫内妊娠,行负压吸引术。血清和尿HCG均阴性29例(29/80,36.25%)为非妊娠组,给米非司酮后48小时,15例(15/29,51.72%)出血,给米索前列醇72小时后,12例(12/29,41.38%)出血,累计27例(93.10%);2例HCG阴性,观察至45天后出血。结论药物催经是减少手术流产的一项可供选择的补救方法。
Objective To evaluate clinical efficacy and adverse effect of Mifepristone combined with Misoprostol used in menstrual regulation. Methods 80 women with menstrual delayed less than 7 days were given 150 mg Mifepristone orally and after 48 hours 400 μg Misoprostol placed in vagina. Adverse effect such as bleeding and elytro-discharge was observed. Results There was 51 cases （51/80,63.75%） with positive result in HCG blood test classified as gestation group including 45 cases （45/51,88.24%） with complete abortion and 2 cases （2/51,3.92%） bleeding for more than 10-day with uterine curettage the tissue of which was identified as deciduous tissue by pathological examination. 4 cases （4/51,7.84%） with no bleeding were diagnosed intrauterine pregnancy by B-ultrasound and performed vacuum aspiration. 29 cases with negative result in HCG blood test classified as non-gestation group were given Mifepristone 48-hour later,there were 15 cases（15/29,51.72%） bleeding. Mifepristone given 72-hour later,12 cases （12/29,41.38%） were observed bleeding,which added to a total of 27 bleeding cases（27/29,93.10%）. 2 cases in this group with negative HCG result were not observed bleeding until 45 days later. Conclusion Medication method of menstrual regulation was proved to be an alternative to operative abortion.
出处
《中国计划生育和妇产科》
2010年第2期7-9,共3页
Chinese Journal of Family Planning & Gynecotokology
基金
洛氏基金会赞助项目"米非司酮降低非意愿妊娠和人工流产的合作研究与开发"中"米非司酮与米索前列醇用于催经的研究"成都分中心的资料(基金项目号:9802)
关键词
米非司酮
米索前列醇
催经
效果
Mifepristone
Misoprostol
menstrual induction
efficacy
