摘要
轮状病毒(RV)是引起全球5岁以下婴幼儿腹泻最重要的病原之一,普遍流行于发达国家和发展中国家,然而在发展中国家该病的病死率较高。由于目前RV腹泻尚无有效治疗药物,并且改善卫生条件对预防RV感染并无明显的效果。因此,疫苗是目前证实能预防和控制RV腹泻唯一有效的手段。尽管RV疫苗研制已取得很大的进展,由于轮状病毒毒株的多样化和流行分布很广,故而继续研制一种新的适合的安全、有效的RV疫苗显得尤为重要。本文针对人RV疫苗的研究进展、质量控制、保护效力及安全性评价作一综述,以期促进后期相关研究。
Rotavirus is a primary pathogen of infantile diarrhea under the age of five.Rotavirus infection is very popular in developed and developing countries,with similar morbidity,but the mortality is higher in developing countries.There has been no effective treatment at present and further improvement in hygiene to control the spread of rotavirus.So developing safe and effective vaccine is the best way for prevention of rotavirus diarrhea,in order to effectively reduce the morbidity and mortality.Although great progress has been achieved in rotavirus vaccine development,there are still many problems（such as the diversity and wide distribution of rotavirus）in the current rotavirus vaccines industry.Therefore,it＇s of great importance to develop sequentially navel rotavirus vaccine.The research progresses in human RV vaccine,quality control,protective efficiency and safety evaluation are reviewed in this paper for the pathogenic characteristics and the immune mechanism of the rotavirus.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2015年第6期583-588,共6页
Chinese Journal of Zoonoses
基金
国家国际科技合作项目(No.2011DFA30750)
北京市科技计划项目(No.Z141100000514010)联合资助~~
关键词
人轮状病毒
疫苗进展
质量控制
保护效力
安全性
human rotavirus vaccine
progress of vaccine research
quality control
protective efficiency
safety
