摘要
线粒体动力学即线粒体融合和分裂保持动态平衡的过程,线粒体的融合与分裂过程决定线粒体形态的可塑性。这种动态平衡的稳定是维持线粒体功能和机体功能的前提和基础,并且受多种化学酶及蛋白等因素调节。因线粒体为细胞能量代谢中心,故线粒体动力学与人类代谢性疾病的关联日益受到重视。近年来,大量研究表明,线粒体动力学失衡可以引起胰岛素抵抗和β细胞功能障碍,并且与糖尿病并发症发生密切相关。
Mitochondrial dynamics is Mitochondrial fission and fusion are the main a dynamic equilibrium between fusion and fission. processes governing the morphological plasticity. Such dynamic equilibrium is a fundamental process that maintains the function of mitochondria and cells and is regulated rolls by multiple factors such as mechanochemical enzymes and accessory proteins. Mitochondria are at the center of cellular energy metabolism. Thus mitochondrial dynamics has drawn much attention because of its implications for metabolic diseases. Emerging evidence suggests that mitochondrial dynamics plays an important role in energy metabolism and secretion coupling in pancreatic β-cells as well as complications of diabetes. This review outlines the mechanisms and functional aspects in mitochondrial fusion and fission, and comments on recent advances in connecting mitochondrial dynamics with type 2 diabetes and diabetic complications.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2015年第3期339-347,共9页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金(81170745)~~
关键词
线粒体动力学
线粒体疾病
2型糖尿病
糖尿病并发症
mitochondrial dynamics
mitochondrial diseases
type 2 diabetes mellitus
diabetescomplications
