摘要
目的探讨宫颈癌组织中Sam68蛋白的表达及其与宫颈癌患者临床预后之间的关系。方法对笔者收集的78例宫颈癌患者的相关资料进行分析,将其设置为实验组,选择同期入院的20例良性宫颈肿瘤患者,将其设置为对照组,采用Power Vision二步法对患者Sam68蛋白进行检测,分析Sam68蛋白表达差异及其临床病理因素、与患者治疗预后的关系。结果宫颈癌患者Sam68蛋白阳性表达率为60.3%(47/78),宫颈良性肿瘤者Sam68蛋白不表达或弱表达,两者比较差异有统计学意义(P<0.05);宫颈癌患者中Sam68蛋白表达与患者的年龄、肿瘤细胞的分化程度无明显相关性(P>0.05);Sam68蛋白表达与肿瘤的大小、TNM分期以及患者淋巴结状态存在明显相关性(P<0.05);Sam68蛋白表达水平和患者总生存时间以及无病生存时间存在相关关系(P<0.05);Sam68蛋白高表达患者5年总生存率(70%)低于Sam68蛋白低表达者(87%);Sam68蛋白高表达者5年无病生存率(53%)低于Sam68蛋白低表达者(79%)。结论患者体内Sam68蛋白和宫颈癌临床病理特征、患者生存期之间关系密切,Sam68蛋白含量越高,患者预后越长,可以将其作为宫颈癌预后的生物学指标。
Objective To investigate the expression of Sam68 protein in cervical cancer and cervical cancer,and the correlation between clinical outcomes between patients. Methods 78 cases of cervical cancer with related data analysis were chosen and set to the experimental group and 20 patients with benign cervical cancer patients admitted to the same period were chosen and set to the control group,the two-step Power Vision was used to detecte Sam68 protein in patients,the relationship between differences and Sam68 protein expression and clinicopathological factors for patients prognosis were analyzed. Results The Sam68 protein expression rate in patients with cervical was 60.3%（47/78）,Sam68 protein in patients with benign cervical was not expressed or weakly expressed,there was significant difference（P〉0.05）;the expression of Sam68 protein in cervical cancer patients had no significant correlation with age and the degree of differentiation and tumor cells in patients（P〈0.05）;the expression of Sam68 protein had significant correlation with the tumor size,TNM stage and lymph node status in patients（P〈0.05）;the expression of Sam68 protein had significant correlation with the survival time and disease-free survival time（P〈0.05）;5-year overall survival in patients with Sam68high-protein expression（70%） was lower than that in patients with Sam68 low-protein expression（87%）.5-year diseasefree survival in patients with Sam68 high-protein expression（53%） was lower than that in patients with Sam68 lowprotein expression（79%）. Conclusion Sam68 protein has the close relationship between the clinicopathological features and survival of cancer patients,the higher the Sam68 protein content,the longer prognosis,it can be used as biological indicators of cancer prognosis.
出处
《中国当代医药》
2015年第18期11-13,共3页
China Modern Medicine
