摘要
目的:观察抑肝散治疗儿童注意缺陷多动障碍(ADHD)阴虚阳亢证的临床疗效。方法:将符合本研究纳入和排除标准的94例ADHD患者分为对照组和观察组各47例。两组均采用盐酸哌甲酯片,5 mg/次,2次/d。对照组服用静灵口服液,10 m L/次,2次/d。观察组内服抑肝散,1剂/d。两组疗程均为12周。进行治疗前后斯诺佩评估(SNAP-Ⅳ)量表(父母版),美国康纳(Conner)设计的简易多动症行为评价量表、韦氏智力量表和阴虚阳亢证评分。结果:两组临床疗效经Ridit分析,观察组优于对照组(P<0.05);治疗后观察组SNAP-Ⅳ量表和阴虚阳亢证评分低于对照组(P<0.01);治疗后观察组Conner量表学习、品行、身心障碍、冲动-多动、焦虑及多动指数等因子评分均低于对照组(P<0.01);治疗后观察组韦氏智力量表的言语理解指数(VCI),知觉推理指数(PRI),工作记忆指数(WMI),加工速度指数(PSI),一般能力指数(GAI),认知熟练指数(CPI),总智商(FSIQ)等因子评分均高于对照组(P<0.01)。结论:抑肝散配合盐酸哌甲酯片能降低ADHD儿童阴虚阳亢证,SNAP-Ⅳ评定量表和Conner行为评价量表各因子评分,并能升高韦氏智力量表各因子评分,能改善ADHD的症状,提高患者的智力水平,临床疗效优于静灵口服液。
Objective： To observe clinical effect of Yigan San in treating attention deficit hyperactivity disorder （ADHD） combined with hyperactivity syndrome. Method： Ninety-four patients with ADHD were randomly divided into control group （47 cases） and observation group （47 cases） by random number table. Both group received methylphenidate hydrochloride tablets for a continued 12 weeks, 5 rag/time, 2 times/day. Patients in control group received Jingling oral liquid, 10 mL/time, 2 times/day, patients in observation group received of Yigan San, 1 dose/day. Treatment courses were continuing for 12 weeks. Before and after treatment, score the Swanson, Nolan, and Pelham, Version IV （SNAP-IV） scale （parent version） , Conner behavior assessment scale, Wechsler intelligence and syndrome of hyperactivity of Yang due to Yin deficiency. Result： By Ridit analysis, clinical curative effect in observation group was superior to that in control group （P 〈 0.05）. The SNAP-IV scale and syndrome of hyperactivity of Yang due to Yin deficiency scores in observation group were less than those in control group （P 〈 0.01 ）. Factor scores as Conner scale learning, moral, physical and mental disabilities, impulse and hyperactivity, anxiety and more dynamic index in observation group were lower than those in control group （P 〈0.01）. Wechsler intelligence such as Verbal comprehension index （VCI） , index （PRI） perception reasoning, working memory （WMI）, processing speed index （PSI）, general ability index （GAI）, cognitive skill index （CPI）, the general intelligence （FSIQ） scores in observation group were better than those in control group （ P 〈 0.01 ）. Conclusion ： Yigan San can reduce each factor score as syndrome of hyperactivity of Yang due to Yin deficiency, SNAP-IV rating scale and Conner behavior assessment scale with ADHD children, enhance Wechsler intelligence each factor scores. It can promote ADHD symptoms and patient＇s level of intelligence. The clinical cura
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2015年第14期145-148,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
唐山市级发展与指导计划项目(10130233a)
关键词
注意缺陷多动障碍
阴虚阳亢证
抑肝散
斯诺佩评估量表
美国康纳行为量表
韦氏智力量表
attention deficit hyperactivity disorder
hyperactivity syndrome
Yigan San
Sinuopeiassessment scale
Conner behavior scale
Wechsler intelligence table
