摘要
目的探讨冠状动脉粥样硬化性心脏病患者早上和睡前服用阿司匹林的临床效果。方法选择2013年6月至2014年6月在我院住院治疗的稳定型冠心病患者87例,将其随机分为早晨组42例、晚间组45例,早晨组患者于早晨8点给予100mg阿司匹林肠溶片口服,晚间组患者于晚上8点服用,比较两组患者治疗8周后的临床疗效、血小板聚集率、血清CRP水平以及不良反应发生情况。结果早晨组患者治疗总有效率为90.48%,晚间组患者治疗总有效率为84.44%,两组患者差异无统计学意义(P>0.05);治疗后两组患者血小板聚集率以及血清CRP水平均较治疗前显著降低,差异有统计学意义(P<0.05),治疗后两组CRP水平差异无统计学意义(P>0.05),而治疗后早晨组血小板聚集率显著低于晚间组,差异有统计学意义(P<0.05);早晨组患者治疗期间不良反应发生率为9.52%,晚间组患者治疗期间不良反应发生率为28.89%,两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论冠状动脉粥样硬化性心脏病患者早晨服用阿司匹林能够加强其抗血小板凝聚作用,同时有助于降低其消化道不良反应,推荐早晨服药。
Objective To investigate the clinical effect of patients with coronary heart disease before and the morning tak-ing aspirin. Methods From 2013 June to 2014 June,87 cases with stable coronary heart disease treated in our hospital,which were randomly divided into morning group（42 cases）and evening group（45 cases）,patients in the morning group to give 100mg Aspirin Enteric-coated Tablets oral at 08：00,and the evening group at 20：00. Comparison of the clinical curative effect,the rate of platelet aggregation,serum CRP levels and the incidence of adverse reactions after 8 weeks of treatment between two groups. Re-sults In the morning group,the total effective rate was 90. 48%,the evening group was 84. 44%,there was no significant differ-ence between the two groups（P〉0. 05）. After treatment,platelet aggregation rate and serum CRP levels of two groups were signifi-cantly lower than those before treatment（P〈0. 05）,t the CRP levels in the two groups had no significant the difference after treat-men（P〉0. 05）,while the morning group’s platelet aggregation rate was significantly lower than that in evening group（P〈0. 05）. Adverse reaction rate was 9. 52% of the morning group during treatment,the evening group was 28. 89%,the difference was statis-tically significant （ P 〈0. 05 ） . Conclusion Patients with coronary atherosclerotic heart disease take aspirin in morning could strengthen their anti platelet aggregation effect,and helps to reduce the adverse reaction of digestive tract.
出处
《四川医学》
CAS
2015年第6期835-837,共3页
Sichuan Medical Journal
