摘要
目的探讨三维适形放疗(3D-CRT)同步紫杉醇+顺铂(TP)方案化疗联合深部热疗对局部晚期非小细胞肺癌(NSCLC)的近期疗效和预后的影响。方法回顾性分析2009年7月—2011年6月邢台医学高等专科学校第二附属医院放疗科收治局部晚期NSCLC 79例,分为观察组41例,对照组38例。观察组采用3D-CRT同步TP方案化疗联合深部热疗,对照组仅给予3D-CRT。比较两组近期疗效、KPS评分改善、生存情况及毒性反应发生率。结果观察组近期疗效和获益率高于对照组,KPS评分改善优于对照组(P<0.05)。两组第1年存活率比较差异无统计学意义(P>0.05),观察组第2、3年存活率高于对照组,3年中位生存期长于对照组(P<0.05)。两组毒性反应发生率比较差异无统计学意义(P>0.05)。结论 3D-CRT同步TP方案化疗联合深部热疗对局部晚期NSCLC近期疗效和延长生存期有积极意义。
Objective To study effects of three dimensional conformal radiation therapy（3D-CRT） synchronizing Paclitaxel and Cisplatin（ TP） chemotherapy combined with deep therapy on short-term curative effect and prognosis of patients with locally advanced non-small-cell lung cancer（ NSCLC）. Methods Clinical data of 79 patients with locally advanced NSCLC during July 2009 and June 2011 was retrespectively analyzed,and they were divided into observation group（ n = 41） and control group（ n = 38）. The observation group was treated with 3D-CRT synchronizing TP chemotherapy combined with deep therapy,while the control group was treated with 3D-CRT only. The short-term curative effect,Karnofsky score（ KPS） improvement,survival condition and incidence rate of toxic reaction in the two groups were compared. Results The short-term curative effect was significantly improved,and the KPS improvement value was also higher than those in the control group（ P〈0. 05）. There was no significantly difference in the 1^st year survival rate in the two groups（ P〉0. 05）,but in the observation group,the 2^nd and 3^rd years survival rates were higher,and the 3years midterm survival period was longer than those in the control group（ P〈0. 05）. The difference in incidence rate of toxic reaction in the two groups was not statistically significant（ P〉0. 05）. Conclusion The 3D-CRT synchronizing TP chemotherapy combined with deep therapy can positively affect short-term curative effect and lengthen survival period in treatment of patient with locally advanced NSCLC.
出处
《解放军医药杂志》
CAS
2015年第5期37-40,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
癌
非小细胞肺
三维适形放疗
抗肿瘤联合化疗方案
微波热疗
Carcinoma
non-small-cell lung
Three dimensional conformal radiation therapy
Antineoplastic combined chemotherapy protocols
Microwave thermotherapy
