摘要
目的探讨3.0T磁共振弥散加权成像(DWI)在前列腺癌(PCa)诊断中的价值,并分析感兴趣区表观弥散系数值(ADC)与临床分期、血清前列腺特异性抗原(PSA)的相关性。方法分析经穿刺活检或手术病理确诊的47例PCa患者,所有患者均行常规MRI扫描及DWI检查,在常规MRI图像上观察前列腺病灶的位置、大小、信号及累计范围,观察病灶区DWI信号并测量ADC值。结果 47例PCa患者中,29例位于外周带,14例位于中央带,4例同时累及中央带和外周带,所有病例DWI上均表现为高信号或稍高信号,在相应ADC图上表现为低信号或稍低信号;PCa病灶平均ADC值约为(0.97±0.33)×10-3mm2/s,与临床分期及血清PSA呈负相关(r值分别为-0.54,-0.66,P<0.05)。结论 MRI常规序列联合DWI检查及血清PSA检测可以提高PCa的诊断,测量病灶的ADC值有助于对PCa的临床分期进行初步评估,进而指导临床选择合适的治疗方案。
Objective To evaluate the diagnostic value of 3.0T diffusion weighted imaging（DWI） in prostate cancer and to analyse the correlation between ADC-value, clinical stage and PSA. Methods The clinical data of 47 cases diagnosed as prostate cancer after biopsy or operation pathologically were analysed; all patients underwent routine MRI scanning and DWI examination, on MRI routine scan the le- sions of the prostate position, size, signal and accumulated in the range were observed,then the focus DWI signal was observed and ADC-val- ue was determined. Results Among 47 cases of prostate cancer, 29 were located in the peripheral zone, 14 in the central zone, and 4 in the central and peripheral zone; all of the cases＇DWI show high signal or slightly high signal, and on corresponding area ADC showed low signal or slightly low signal; the average ADC-value was （0. 97 ＋ 0.05 ） x 10-3mmZ/s. Negative correlation was found with clinical stage and PSA （r = -0.54, -0. 66, P 〈 0.05）. Conclusion MRI routine scan and DWI examination and PSA test can improve the diagnosis of prostate cancer, and measuring focus ADC-value can be helpful to estimate the clinical stage, and further guide the clinicians to select appropriate treatment options.
出处
《安徽医学》
2015年第6期650-653,共4页
Anhui Medical Journal
基金
安徽省卫生和计划生育委员会中医药科研课题基金(项目编号:2014zy30)
关键词
弥散加权成像
表观弥散系数
前列腺特异性抗原
前列腺癌
Diffusion weighted imaging
Apparent diffusion coefficient
Prostate specific antigen
Prostate cancer
