摘要
利用基因芯片技术对肿瘤细胞基因表达谱进行分析。通过筛选出不同肿瘤个体及不同肿瘤类型具有特征性的差异表达基因，以达到利用差异表达基因对肿瘤进行诊断与鉴别诊断的目的。这些被筛选出的差异表达基因不仅与肿瘤组织的生长发育、增殖凋亡和信号传导有关，而且与肿瘤的发病机制、浸润转移、肿瘤的抗药性有关，尤其是一些肿瘤差异表达基因或基因组显示与肿瘤的组织学来源及组织学类型相关联。基因表达谱在临床肿瘤病理诊断与鉴别诊断中具有实际应用价值。
Through analyzing the gene expression profile of tumor cells with gene chip technology and se -lecting the differentially expressed genes of different tumor individuals and tumor types ,researchers find that these genes are not only connected with tumor growth ,proliferation,apoptosis,and signal transduction,but also with tumor pathogenesis,tumor infiltration,tumor metastasis and tumor drug resistance .Some tumor differentially ex-pressed genes or genomes show that these genes are even associated with tumor histological source and histological type.It demonstrates practical application value in the pathological diagnosis and differential diagnosis of tumors .
出处
《实用肿瘤学杂志》
CAS
2015年第3期275-278,共4页
Practical Oncology Journal
关键词
基因表达谱
鼻咽癌
肺癌
胃癌
结直肠癌
Gene expression profiling
Nasopharyngeal carcinoma
Lung carcinoma
Gastric cancer
Colo-rectal cancer
