摘要
目的观察维持性血液透析患者骨密度异常发生情况,分析骨密度异常与年龄、性别、透析时间以及骨代谢异常相关因素i PTH、钙、磷的关系。方法 1采用横断面调查方法观察维持性血液透析患者年龄、性别、透析龄及相关生化指标,采用定量超声检查法,测量263例维持性血液透析患者骨密度(BMD)值;2.采用pearson相关分析及Logistic回归方法分析年龄、性别、透析时间及骨代谢相关生化指标对骨质疏松的影响。结果 1维持性血液透析患者中,骨密度异常占90.12%,其中骨质疏松者占45.62%,低骨量者占44.48%,正常骨量占9.88%。2年龄与骨密度值呈负相关(r=-0.242,P=0.000),随着年龄的增长,骨质疏松发生的危险性增加1.352倍;女性骨质疏松发生率(58.62%)较男性(34.69%)明显增高,差异有统计学意义(χ2=14.980,P=0.000),女性发生骨质疏松的危险性是男性的2.46倍;透析龄与骨密度值呈负相关(r=-0.198,P=0.030);随着血磷的升高,骨质疏松发生的危险性增加1.33倍。3维持性血液透析患者中,骨密度值与血钙、血磷、血i PTH无相关性,将患者的年龄、性别、血清钙、血清磷、血i PTH等数据引入Logistic回归模型,筛选出年龄、性别、血磷为最终影响预后的因素,女性、高龄以及高磷血症为患者骨质疏松的危险因素。结论维持性血液透析患者骨密度异常发生率高,年龄、女性、透析龄以及高磷血症均是发生骨质疏松的危险因素。
Objective To observe the abnormal bone mineral density （BMD） in maintenance hemodialysis （MHD） patients, and to correlate BMD with age, sex, dialysis vintage, and bone metabolic related indica- tors including serum iPTH, calcium and phosphorus, Methods This was a cross-sectional study to measure BMD value by quantitative ultrasound in 263 MHD patients and to observe their age, gender, dialysis vintage, and bone metabolism related indicators, Results OAbnormal BMD was found in 90.12% MHD patients, including osteoporosis in 45.62% patients and low bone mass in 44.48% patients. ~）Age was negatively corre- lated with BMD value （I=-0.242, P=-0.000）. The risk of osteoporosis increased 1.352 folds with the increase of age. The prevalence of osteoporosis was 58.62% in females significantly higher than that in males （34.69%;χ2= 14.980, P=0.000）. The risk of osteoporosis in females was 2.46 times higher than that in males. Hemodialy- sis vintage was negatively correlated with BMD value （r=-0.198, P=0.198）. The risk of osteoporosis increased 1.33 folds with the increase of serum phosphorus. Conclusion The prevalence of abnormal BMD was high- er in MHD patients. Age, female, hemodialysis vintage and hyperphosphatemia were the risk factors for osteo- porosis.
出处
《中国血液净化》
2015年第6期325-327,共3页
Chinese Journal of Blood Purification
基金
咸阳市重大科技计划项目(2013K1201)
