摘要
目的 探讨甲状旁腺切除术对尿毒症血液透析患者血磷及骨代谢的影响,分析影响血磷的主要因素.方法 选取2008年1月～2013年12月在复旦大学附属华山医院接受甲状旁腺切除术的尿毒症继发性甲状旁腺功能亢进患者,收集患者术前1天、术后1、3和7天的血清及血浆标本,检测各时间点各项血生化指标、调磷因子及骨代谢指标,并进行相关性分析.结果 甲状旁腺切除术后各时间点（1、3、7天）血甲状旁腺素（PTH）水平较术前明显下降,差异有统计学意义.同时,术后3天的血磷水平从术前2.26±0.55mmol/L明显下降至正常水平1.37±0.40mmol/L （P＜0.01）.术后血成纤维细胞生长因子23（FGF23）水平逐渐下降,至术后7天与术前相比具有显著下降（418.65±280.74 pg/mL vs.680.75±307.71 pg/mL）.同时,术后1天血清骨特异性碱性磷酸酶（BAP）由术前727.50±30.14U/L降至551.25±60.61U/L,Ⅰ型胶原交联羧基末端肽（ICTP）由术前20.11±2.56 μ g/L降至13.75±2.95 μ g/L,差异均有统计学意义.相关性分析显示血磷与PTH、血钙、FGF23、25羟维生素D3 （25 （OH） D3）、BAP及ICTP均有显著相关性,但多因素回归分析证实血浆FGF23水平是影响血磷的决定因素.结论 甲状旁腺切除术可以显著纠正高磷血症,改善骨代谢异常,骨骼产生的FGF23是决定血磷的关键因素.
Objective To explore the effects of parathyroidectomy（PTX） on serum phosphate level and bone metabolism in uremic hemodialysis patients,and to analyze the primary factors which affect serum phosphate level.Method Uremic patients with secondary hyperparathyroidism treated with PTX in our hospital during the period from Jan.2008 to Dec.2013 were enrolled in this study.Serum and plasma samples were collected before PTX and after PTX for 1,3 and 7 days and clinical data were recruited.Correlations among these data were analyzed.Result Serum PTH significantly decreased after PTX for one day as compared with the level before PTX.Serum phosphate decreased from 2.26 ± 0.55 mmol/L before PTX to 1.37 ±0.40 mmol/L after PTX for 3 days（P〈0.01）.Plasma FGF23 also decreased gradually after PTX.Plasma FGF23 decreased from 680.75±307.71 pg/m L before PTX to 418.65±280.74 pg/m L after PTX for 7 days（P〈0.01）.Serum bone-specific alkaline phosphatase（BAP） reduced from 727.50 ± 30.14 U/L before PTX to551.25 ± 60.61 U/L after PTX for one day（P〈0.01）.Serum type I collagen cross-linked C-terminal peptide（ICTP） decreased from 20.11 ± 2.56 μg/L before PTX to 13.75 ± 2.95 μg/L after PTX for one day（P0.05）.Pearson correlation analysis found that serum phosphate level correlated with the levels of serum PTH,calcium,FGF23,25（OH）D3BAP and ICTP.Multivariate regression analysis demonstrated that FGF23 was the factor determining serum phosphate level.Conclusion Parathyroidectomy significantly alleviates the higher serum phosphate and improves bone metabolism.Bone derived FGF23 is a decisive factor on serum phosphate level.
出处
《中国血液净化》
2015年第5期256-260,共5页
Chinese Journal of Blood Purification
基金
国家自然科学基金(81170684)
上海市优秀学科带头人培养计划(XBR2013080)
