摘要
目的观察比索洛尔联合音乐疗法稳定原发性高血压患者静息心率及交感神经活性的效果。方法将186例原发性高血压患者随机分为对照组、观察1组和观察2组,各62例。对照组患者采用苯磺酸氨氯地平片治疗,观察1组患者在对照组基础上加用比索洛尔,观察2组患者在观察组1基础上联合音乐疗法,疗程均为30 d。结果 3组患者收缩压及舒张压均明显降低(P<0.05),组间比较,差异无统计学意义(P>0.05)。对照组患者静息心率较治疗前下降不明显(P>0.05),观察1组及2组均显著下降(P<0.05),观察2组下降更显著(P<0.05)。观察1组及2组患者血浆去甲肾上腺素、肾素和血管紧张素Ⅱ水平均显著降低(P<0.05),对照组仅去甲肾上腺素和肾素降低(P<0.05),血管紧张素Ⅱ无显著改变(P>0.05),观察1组和观察2组患者3种指标均低于对照组,且观察2组下降更明显(P<0.05)。3组患者治疗过程中不良反应发生率比较无明显差异。结论比索洛尔联合音乐疗法治疗原发性高血压安全、有效,能显著降低患者静息心率,稳定交感神经活性,值得临床推广。
Objective To observe the effect of bisoprolol combined with the music therapy for stabilizing the resting heart rate and sym-pathetic nerve activity in the patients with essential hypertension. Methods Totally 186 patients with essential hypertension were randomly divided into the control group,observation group 1 and observation group 2,62 cases in each group. The control group was treated by Amlodipine Besylate Tablets,the observation group 1 was added with bisoprolol on the basis of the control group and the observation group 2 was combined with the music therapy on the basis of the observation group 1. The treatment in 3 groups lasted for 30 d. Results The systolic and diastolic blood pressure of the 3 groups were significantly decreased than before treatment（ P 〈 0. 05）,but there was no statistically significant difference among 3 groups（ P 〉 0. 05）. The decrease of resting heart rate after treatment in the con-trol group was unobvious compared with before treatment（ P 〉 0. 05）,but which in the observation group 1 and 2 were obvious,the dif-ference was statistically significant（ P 〈 0. 05）;the decrease in the observation group 2 was more significant than that in the observation group 1（ P 〈 0. 05）. The plasma norepinephrine,renin and angiotensin Ⅱlevels after treatment in the observation group 1 and 2 were decreased significantly（ P 〈 0. 05）,but only plasma norepinephrine and renin levels in the control group were decreased（ P 〈 0. 05）,the angiotensin Ⅱlevel had no significant change（ P 〉 0. 05）;in the comparison among groups,the 3 indexes levels in the observation group 1 and 2 were lower than those in the control group,moreover the decrease in the observation group 2 was more significant than that in the observation group 1（ P 〈 0. 05）. The occurrence rate of adverse reactions during the treatment process had no significant differences among 3 groups. Conclusion Bisoprolol combined with the music therapy in the treatment process of essential hyperte
出处
《中国药业》
CAS
2015年第12期38-40,共3页
China Pharmaceuticals
关键词
比索洛尔
音乐疗法
原发性高血压
静息心率
交感神经活性
bisoprolol
music therapy
essential hypertension
resting heart rate
sympathetic nerve activity
