摘要
目的:通过Lequesne指数评分,比较早期膝关节骨性关节炎(OA)患者膝关节腔内分别注射透明质酸钠与糖皮质激素复方倍他米松的治疗效果[1]。方法:100例膝骨关节炎患者随机平均分为玻璃酸钠组与激素组,每组各50例。临床评估即Lequesne指数评分,评估是分别在第1、3、6个月评测。结果:在第1个月时,两组患者之间Lequesne指数评分均明显降低,与治疗前比较具有统计学意义;第3个月开始两组患者评分持续降低,但透明质酸钠组患者的Lequesne评分显著低于激素组;第6个月时,两组患者的Lequesne评分有回升趋势,数据显示两组中玻璃酸钠组评分回升显著慢于激素组,玻璃酸钠组患者的治疗后效果更为持久。结论:早期OA患者关节腔注射透明质酸与激素治疗可明显降低膝关节的Lequesne指数评分,但关节腔内注射玻璃酸钠效果更佳。
Objective： To compare clinical effects of sodium hyaluronate and glucocorticoid in treatment of early knee osteoar-thritis （OA） though Lequesne index score. Methods： 100 patients with osteoarthritis were randomly divided into sodium hyaluronate group and glucocorticoid group. The clinical assessments （Lequesne index score） were done at 1, 3, and 6 months. Results： At the first month, the Lequesne index scores of the two groups were significantly reduced, and the differences before and after the treatment were statistically significant. At the third month, the Lequesne index scores of the two groups continued to decrease ; however, the Lequesne index score of sodium hyaluronate group was significantly lower than that of glucocorticoid group. At the sixth month, the two groups showed a rebounding trend of the Lequesne index score, and the data showed that the sodium hyaluronate group score signifi- cantly rebounded slower than that of glucocorticoid group, indicating the therapeutic effect of sodium hyaluronate group was more durable than glucocorticoid group. Conclusions： For the Patients with early OA, sodium hyaluronate and glucocorticoid both can significantly reduce the Lequesne index score, but the intra-articular injection of sodium hyaluronate has a better therapeutic effect.
出处
《中国民康医学》
2015年第12期17-18,共2页
Medical Journal of Chinese People’s Health
