摘要
目的：观察乙醛脱氢酶1（ALDH1）、CD133在鼻咽癌组织中的表达及其临床意义。方法检测鼻咽癌组织135例（研究组）以及正常组织97例（对照组）标本中的ALDH 1、CD133表达情况，并统计分析其与鼻咽癌患者临床资料的关系。结果（1）研究组ALDH1阳性表达率为75．56％（102／135），高于对照组的42．30％（42／97）（χ2＝24．945， P ＜0．05）。 ALDH 1评分在鼻咽癌患者性别、年龄、原发癌／转移癌、未分化癌／分化型以及有无颈淋巴结转移等不同临床资料间无显著性差异（ t ＝0．543、0．034、0．022、0．356、0．382， P均＞0．05）。（2）研究组CD133阳性表达率为35．56％（48／135），高于对照组的12．37％（12／112）（χ2＝15．824 P ＜0．05）。 CD133的表达在患者原发癌／转移癌、未分化癌／分化型不同资料间比较差异有统计学意义（χ2＝15．028、5．186， P均＜0．05），在患者性别、年龄以及有无颈部淋巴结转移等不同临床资料间比较差异无统计学意义（χ2＝1．545、0．000、0．036， P ＞0．05）。结论ALDH1与CD133在鼻咽癌患者中均有较高的阳性表达率，ALDH1的临床价值需进一步研究，而CD133可能与鼻咽癌转移、病理分型有密切的关系。
Objective To observe the expression of aldehyde dehydrogenase 1 （ALDH-1）, CD133 in nasopharyngeal carcinoma and its clinical significance.Methods Nasopharyngeal carcinoma （ NPC） of 135 cases （ study group） and normal tissue of 97 cases （ control group） were detected with the ALDH-1 and CD133 expression, and statistical analyzed its relation-shipwithclinicaldataforthepatientswithNPC.Results （1）Studygroup’sALDH-1positiveexpressionratewas75.56%（102/135）, which was higher than the control group’s 42.30%（42/97） （χ2 =24.945, P 〈0.05）.ALDH-1 score in naso-pharyngeal carcinoma patients’ gender, age, primary carcinoma /metastatic carcinoma, undifferentiated/differentiation car-cinoma and cervical lymph node metastasis did not show significant difference （ t =0.543, t =0.034, t =0.022, t =0.356, t =0.382, P 〉0.05）.（2） Study group’s CD133 expression rate was 35.56%（48/135）,which was higher than in the con-trol group 12.37%（12/112） （χ2 =15.824, P 〈0.05）.The expressions of CD133 in patients with primary cancer /meta-static carcinoma, undifferentiated /differentiated carcinoma have significant difference （χ2 =15.028,χ2 =5.186, P 〈0.05）.Gender, age, and with or without cervical lymph node metastasis showed no significant difference （χ2 =1.545,χ2 =0.000,χ2 =0.036, P 〉0.05）.Conclusion ALDH-1 and CD133 in patients with nasopharyngeal carcinoma （NPC） had higher positive expression rate, ALDH-1’s clinical value needs to be further studied, and CD133 may have close relationship with nasopharyngeal carcinoma metastasis, pathological type.
出处
《疑难病杂志》
CAS
2015年第6期590-592,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
乙醛脱氢酶1
细胞表面黏附分子
鼻咽癌
肿瘤干细胞
Aldehyde dehydrogenase 1
Cell adhesion molecules
Nasopharyngeal carcinoma
Tumor stem cell
