摘要
目的观察地佐辛与舒芬太尼单独和联合应用预防膀胱肿瘤电切术后尿管相关膀胱刺激征（CRBD）的临床效果。方法择期全身麻醉下行经尿道膀胱肿瘤电切术160例男性患者，按随机数字表法将患者分为四组，每组40例，对照组（C组）静脉注射氯化钠注射液2ml，地佐辛组（D组）静脉注射地佐辛5mg，舒芬太尼组（S组）静脉注射舒芬太尼5μg，地佐辛＋舒芬太尼组（DS组）静脉注射地佐辛5mg＋舒芬太尼5μg。分别记录患者拔除喉罩后即刻（T0）及1h（T1）、2h（T2）、6h（T3）后CRBD发生情况、镇静程度和不良反应。结果在各时间点。D、S、DS组CRBD的发生率及程度与C组比较均降低．差异有统计肇意义（P〈0．05）．T0时刻．DS组与D、S组比较，CRBD发生率及程度均降低，差异有统计学意义（P〈0．05）。哟时刻，与C组比较，D、S、DS组镇静程度升高，差异有统计学意义（P〈0．05）。结论地佐辛与舒芬太尼均可一定程度的预防膀胱肿瘤电切术后CRBD的发生，二者联合应用预防膀胱肿瘤电切术后CRBD效果更好，不良反应轻微。
Objective To observe the effect of dezocine and sufentanil on preventing catheter-related bladder dis- comfort（CRBD） after transurethral resection of bladder tumor resection. Methods One hundred and sixty male patients, ASA Ⅰ-Ⅲ, aged 48 -68 years, with a body mass index of 18 -25 kg/m^2 , scheduled for transurethral bladder tumor re- section under general anesthesia, were randomly divided into four groups, with 40 cases in each group. The patients of con- trol group （group C） were intravenously injected with saline 2 ml; the patients of dezocine group （group D） were intrave- nously injected with dezocine 5 mg; in sufentanil group（ group S） , the patients were intravenously injected with sufentanil 5 p.g; in the dezocine combined with sufentanil group （group DS）, patients were intravenously injected with sufentanil 5 μg and dezocine 5 mg. The incidence of CRBD, sedation level and adverse reactions were all recorded immediately （T0） and after 1 h（T1 ）, 2 h（T2）, 6 h （T3） removal of laryngeal mask airway. Results Compared with group C, the incidences and levels of CRBD in group D, group S and group DS at any time point decreased （P 〈 0. 05 ）. Compared with group D and group C, the incidence and level of CRBD in group DS decreased further （ P 〈 0. 05 ） at TO time point. At TO time point, the sedation level in group D, group S and group DS were increased as compared with group C （P 〈 0. 05 ）. Conclu- sions Dezocine and sufentanil can prevent the occurrence of CRBD after transurethral resection of bladder tumor resec- tion. Combination of the two drugs has better effect and less adverse reactions in preventing CRBD after transurethral resec- tion of bladder tumor.
出处
《中国实用医刊》
2015年第13期33-36,共4页
Chinese Journal of Practical Medicine
