摘要
目的通过对红细胞沉降率、结核抗体测定、痰结核菌涂片检查以及结核感染T细胞检测4种检查方法的比较,证明结核感染T细胞斑点试验诊断老年人肺结核更具有应用价值。方法 2012年1月-2013年12月收治的肺结核病老年患者中随机抽取100例作为试验组,再选择50例未患肺结核病老年患者作为对照组,分别对两组进行红细胞沉降率、结核抗体测定、痰结核菌涂片检查以及结核感染T细胞检测方法,对比记录4种方法检测效果。结果红细胞沉降率、结核抗体测定、痰结核菌涂片检查及结核感染T细胞检测的阳性率试验组患者分别为83.0%、59.0%、72.0%及98.0%,对照组分别为92.0%、8.0%、2.0%及0,结核感染T细胞检测阳性率高于优于红细胞沉降率检测、结核抗体测定和痰结核菌涂片检查,对比差异有统计学意义(P<0.05);结核感染T细胞检测试验组阳性率较高,对照组无阳性检出,结核感染T细胞检测特异性达98.0%,敏感性100.0%。结论 4种检测方法中,使用结核感染T细胞斑点试验诊断老年人肺结核的检测效果显著,可明显提高诊断准确度,值得临床推广。
OBJECTIVE To investigate the application value of infected T cell spot test in the diagnosis of tuberculosis in elderly patients by comparison of the erythrocyte sedimentation rate , tuberculosis antibody detection ,sputum smear examination and TB infected T cell detection .METHODS A total of 100 cases of elderly patients with TB admitted in the hospital from Jan .2012 to Dec .2013 were chosen as experiment group and another 50 cases without TB were chosen as control group .Erythrocyte sedimentation rate ,tuberculosis antibody detection ,sputum smears examination and tuberculosis infection of T cells detection were conducted to the two groups and the effects were compared .RESULTS The positive rates by the method of erythrocyte sedimentation rate ,tuberculosis antibody assay ,the sensitivity of sputum smear examination and tuberculosis infected T cells detection in the experiment group were 83 .0% ,59 .0% ,72 .0% and 98 .0% and in the control group ,they were 92 .0% ,8 .0% ,2 .0% and 0 .The positive rate of TB infected T cell detection was significantly higher than other three methods （P〈0 .05） .And the rate in the experiment group was high .No positive cases were detected in the control group .The specificity rate of TB infected T cell detection was up to 98 .0% and the sensitivity rate was 100 .0% .CONCLUSION In the four methods ,detection of TB infected T cells has obvious effect in the diagnosis of TB in elderly patients and can improve the accuracy of diagnosis ,hence is worthy to be applied in clinic .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第12期2647-2648,2660,共3页
Chinese Journal of Nosocomiology
基金
山东省医药卫生科技基金资助项目(2013WS0147)
关键词
结核感染
T细胞检测
老年患者
肺结核
TB infected
T cells detection
Elderly patients
Tuberculosis
