摘要
目的探讨不同类型肝炎患者的各项凝血指标,尤其是血小板指标的病理性变化和功能水平以及其检测对各类型肝炎诊断的临床价值。方法抽取96例肝病患者,依据病理机制及病程分为3组,再同期抽取50例健康者作为健康对照组。测定实验组和健康对照组的血浆凝血酶原时间(PT)、凝血酶时间(TT)、部分活化凝血活酶时间(APTT)等各项临床指标,并对检测结果进行统计学处理和分析。结果慢性肝炎、重型肝炎及肝硬化组的4项指标与健康对照组比较差异有统计学意义(P<0.01)。重型肝炎及肝硬化、慢性肝炎患者PT、TT、APTT明显延长,而纤维蛋白原(FIB)水平下降。肝炎患者与健康对照者相比,血小板计数(PLT)、血小板压积(PCT)明显下降,平均血小板体积(MPV)、血小板分布宽度(PDW)明显升高,差异有统计学意义(P<0.01)。结论不同类型肝炎患者的凝血功能均有不同程度的损害,且损害程度与病情进展相关。
Objective To explore the various different types of hepatitis coagulation indicators ,especially indi-cators of pathological changes in platelet and functional levels and the detection of various types of hepatitis diagnos-tic value .Methods 96 cases of patients with liver extract ,according to the pathological mechanism and the course is divided into three groups ,and then extracting the same period 50 healthy persons were being control group .In the experimental group and the control group ,prothrombin time（PT） ,thrombin time（TT） ,activated partial thrombo-plastin time（APTT） and other clinical parameters were determinated ,and the test results were statisticed and analy-sised .Results Those four indicators with chronic hepatitis ,severe hepatitis and cirrhosis groups were significantly different ,compared to healthy control group （P〈0 .01） .PT ,TT ,APTT in the patients of severe hepatitis and liver cirrhosis ,chronic hepatitis ,were prolonged ,and FIB content decreased .Compared with those in control group ,plate-let count ,platelet hematocrit decreased significantly in hepatitis patients （P〈0 .01） ,mean platelet volume ,platelet distribution width was significantly higher （P〈0 .01） .Conclusion Different types of blood coagulation function in patients with hepatitis have varying degrees of damage ,and damage associated with disease progression .
出处
《检验医学与临床》
CAS
2014年第12期1599-1600,共2页
Laboratory Medicine and Clinic
基金
高等学校博士学科重点专项科研基金(200804871049)
关键词
肝炎
血小板
凝血功能
hepatitis
platelets
coagulation
