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系统性红斑狼疮患者激素水平变化与卵巢功能早衰的临床研究 被引量:3

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摘要 目的探讨女性系统性红斑狼疮(SLE)患者激素水平的变化与卵巢功能早衰之间的关系。方法选择我院女性 SLE 住院患者80例和健康体检者77例。采用放射免疫定量法检测两组入选者血浆中黄体生成素(LH)、促卵泡生成素(FSH)、垂体泌乳素(PRL)、雌二醇(E2)、孕酮(P)的含量和红细胞沉降率(ESR)、C 反应蛋白(CRP)水平。结果(1)SLE 组 LH、FSH 明显高于对照组(P <0.05);SLE 组 E2、P 明显低于对照组(P <0.05)。(2)SLE 组确诊为卵巢功能早衰的患者有24例(30%);对照组为0例(P <0.05)。(3)SLE 亚组中,≤30岁组早衰的患者比例与>30岁组比较差异无统计学意义(P >0.05);E2、P 水平在两亚组比较差异亦无统计学意义(P >0.05)。(4)在 SLE 组 E2与 CRP(r =0.382,P <0.05)、ESR(r =0.471,P <0.05)、P(r =0.416,P <0.05)呈正相关。结论SLE 患者体内总体性激素水平降低,FSH 升高,E2、P 水平下降,卵巢早衰的发生率明显高于正常女性。
出处 《临床内科杂志》 CAS 2015年第5期344-345,共2页 Journal of Clinical Internal Medicine
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