摘要
目的探讨多巴胺联合水超滤浓缩回输治疗肝硬化合并顽固性腹水的临床疗效及安全性。方法将老年肝硬化合并顽固性腹水患者61例分为对照组(n=29)和观察组(n=32)。对照组患者采用腹水超滤浓缩回输治疗,观察组患者在对照组治疗的基础上应用多巴胺腹腔内注射治疗;2组患者均给予补充白蛋白、利尿、抗感染、保肝治疗。比较2组患者治疗前后体质量、腹围、尿量、血浆生物化学指标和白蛋白水平,并观察2组患者的不良反应。结果与治疗前比较,2组患者治疗后血浆肾素、血管紧张素Ⅱ、醛固酮水平及体质量、腹围均显著降低(P<0.05),尿量显著增加(P<0.05),血浆白蛋白水平显著升高(P<0.05);治疗后观察组患者血浆肾素、血管紧张素Ⅱ、醛固酮水平及体质量、腹围显著低于对照组(P<0.05),尿量、血浆白蛋白水平显著高于对照组(P<0.05)。治疗后2组患者血浆电解质(钠、钾、钙、氯)水平比较差异无统计学意义(P>0.05)。2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论多巴胺联合水超滤浓缩回输治疗老年肝硬化合并顽固性腹水,疗效确切,安全性高。
Objective To explore the efficacy and safety of water ultrafihration reinfusion combined with dopamine in treating liver cirrhosis patients with refractory aseites. Methods Sixty-one cases of liver cirrhosis patients with refi＇actory asci- tes were divided into control group（ n = 29） and observation group（ n = 32）. The patients in control group were given water ul- trafiltratlon reinfusion,while the patients in observation group were given water ultrafiltration reinfusion combined dopanfine. The patients in the two groups were all given the treatments including supplying albumin, diuresis, anti-infection and protecting liver. The body weight, abdominal circumference, urine volume, biochemical indexes and serum albumin levels in plasma before and after treatment were compared between the two groups. The adverse reactions were observed. Results After treatment, the levels of plasma renin, angiotensin Ⅱ , aldosterone, body weight, abdominal circumference of two groups were significantly lower than those before treatment （ P 〈 0. 05 ）, while the levels of plasma albumin, urine volume of two groups were significantly high- er（ P 〈 0.05 ）. In observation group, the levels of plasma renin, angiotensin Ⅱ , aldosterone, body weight, abdominal circumfer- ence were significantly lower than those in control group after treatment（ P 〈 0.05 ）, while the levels of plasma albumin, urine volume were significantly higher（ P 〈 0.05 ）. There was no significant difference in plasma electrolytes index （sodium ,potassi- um, calcium, chlorine） between the two groups after treatment （P 〉 0. 05）. The incidence of adverse reactions between the two groups had no significant difference （ P 〉 0.05 ）. Conclusion Water ultrafihration reinfusion combined with dopamine in trea- ting liver cirrhosis patients with refractory ascites is effective and safe.
出处
《新乡医学院学报》
CAS
2015年第5期432-434,共3页
Journal of Xinxiang Medical University
关键词
多巴胺
水超滤浓缩回输
肝硬化合并顽固性腹水
安全性
dopamine
water ultrafiltration reinfusion
liver cirrhosis with refractory ascites
safety
