摘要
目的评价益生菌预防老年人抗生素相关性腹泻的疗效。方法计算机检索Pub Med、EMbase、Web of Science、Cochrane系统评价数据库、Cochrane临床对照试验注册库、中国知网、维普、万方,并手工检索相关参考文献等,检索时间跨度为1966年1月-2014年4月。所纳入研究均为随机对照试验,研究对象≥65岁,研究内容为抗生素使用时或使用前预防性使用益生菌,文献Jadad评分须>3分。结果共纳入8篇文献,包含3 680例研究对象(益生菌组1 843例,对照组1 837例)。Meta分析结果显示:益生菌组与对照组间发生抗生素相关性腹泻(AAD)的风险差异无统计学意义[RR=0.76,95%CI(0.51,1.13),P=0.17]。亚组分析发现乳杆菌属[RR=0.59,95%CI(0.31,1.13),P=0.11]、酵母菌属[RR=1.24,95%CI(0.70,2.19),P=0.46]、多种益生菌联合[RR=0.58,95%CI(0.24,1.41),P=0.23]与对照组相比,差异均无统计学意义。结论尚无证据支持益生菌能够降低老年人服用抗生素后发生AAD的风险。
Objective To systematically evaluate the efficacy of probiotics in preventing antibiotic-associated diarrhea （AAD） in aged people. Methods PubMed, Web of Science, the Cochrane Database of Systematic Reviews, the Cochrane Controlled Trials Register, CNKI, VIP, and WANFANG electronic databases were searched for studies published, and references of included studies and reviews were screened from database inception to April 2014. Only randomized, controlled trials involving patients older than 65 years were included. Furthermore, only the trials which combined antibiotic administration and probiotic therapy for the prevention of AAD and Jadad score 〉 3 were extracted. Results A total of eight articles containing 3 680 subjects （1 843 in the probiotic group, 1 837 people in the control group） met the inclusion criteria. Meta-analysis showed that there was no significant difference in the risk of antibiotic- associated diarrhea （AAD） between probiotics and control groups [RR=0.76, 95%CI （0.51, 1.13）, P=0.17]. Further subgroup analysis found that compared with the control group, saccharomyces [RR=1.24, 95%CI （0.70, 2.19）, P=0.46], lactobacillus [RR=0.59, 95%CI （0.31, 1.13）, P=0.11], multi-probiotics combination [RR=0.58, 95%CI （0.24, 1.41）, P=0.23] in the probiotics group were not significantly different. Conclusion There is no evidence to support that probiotics can reduce the risk of AAD among aged people administrated with antibiotics therapy.
出处
《华西医学》
CAS
2015年第5期899-904,共6页
West China Medical Journal
基金
国家自然科学基金(81372982)~~
