摘要
目的:系统评价中药胃管注入治疗对肠梗阻的临床疗效。方法:计算机检索Pub Med、Web of Science、EBSCO、the Cochrane Library、中国期刊全文数据库、万方数据库、维普数据库和中国生物医学数据库,纳入关于中药胃管注入治疗肠梗阻的随机或半随机对照试验,检索时限均为从建库至2014年7月。由两名研究者按照纳入和排除标准进行文献筛选、资料提取、质量评价并交叉核对后,采用Rev Man5.3和Stata 12.0软件进行Meta分析。结果:最终纳入35篇随机对照实验,共3234名患者,Meta分析结果显示:中药胃管注入组在提高肠梗阻总有效率(大承气汤加减组:RR=1.21,95%CI=1.16~1.25,P=0.000;自拟汤剂组:RR=1.23,95%CI=1.16,1.31,P=0.000),治愈率方面优于常规西医治疗组(大承气汤加减组:RR=1.25,95%CI=1.14~1.36,P=0.000;自拟汤剂组:RR=1.38,95%CI=1.24,1.52,P=0.000),中药胃管注入组在缩短肠梗阻平均治疗时间(WMD=-4.27,95%CI=-5.95^-2.60,P=0.000)、恢复排气时间(WMD=-6.67,95%CI=-11.74^-1.60,P=0.001)、恢复排便时间(WMD=-13.29,95%CI=-20.75^-5.84,P=0.001)、肠鸣音消失时间(WMD=-1.28,95%CI=-1.69^-1.03,P=0.000)等方面均优于常规西医疗法组,其差异有统计学意义。结论:中药胃管注入治疗肠梗阻疗效优于常规西医治疗。由于纳入研究质量不高,上述结论尚待开展大样本、多中心研究加以验证。
Objective：To evaluate the effectiveness of Chinese herbal gastrointestinal intubation in the treatment of patients with ileus.Methods：Electronic databases such as Pub Med,Web of Science,EMbase,EBSCO,the Cochrane Library,CNKI,Wan Fang,VIP and CBM were searched from their establishment to July 2014 to meet the inclusion criteria of randomized controlled trials（RCTs）and quasi-randomized trials（quasi-RCTs）. Meta analysis was conducted using Rev Man 5.3 and Stata 12.0 software. Results：A total of 35 RCTs or quasi-RCTs involving 3 234 patients were included. The results of Meta analyses showed that the Chinese herbal gastrointestinal intubation group was superior to control group in raising the total clinical effective rate（Dachengqi decoction group：RR=1.21,95%CI=1.16 to 1.25,P=0.000;other decoction group：RR=1.23,95%CI=1.16 to 1.31,P=0.000）and the cure rate（Dachengqi decoction group：RR=1.25,95%CI=1.14 to 1.36,P=0.000;other decoction group：RR=1.38,95%CI=1.24 to 1.52,P=0.000）as well as in shortening the hospitalization time（WMD=-4.27,95%CI=-5.95 to 2.60,P=0.000）,restoring anus exhausting time（WMD =-6.67,95%CI=-11.74 to 1.60,P=0.001）,restoring defecating time（WMD=-13.29,95%CI=-20.75 to-5.84,P=0.001）and disappear time of bowel sound（WMD=-1.28,95%CI=-1.69 to 1.03,P=0.000）,with statistical differences. Conclusion：Chinese herbal gastrointestinal intubation treatment is superior to basic Western medicine for ileus. Due to limitations to quality of included studies,this conclusion has yet to be carried out in large multicenter study to validate.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2015年第3期371-377,共7页
Journal of Chongqing Medical University
关键词
肠梗阻
中药
胃管注入
系统评价
ileus Chinese herbal gastrointestinal intubation systematic review
