摘要
目的：探讨微生态制剂对小儿血液肿瘤化疗后肠道菌群失调的影响。方法回顾性分析60例血液肿瘤患儿的临床病例资料，将患儿分根据治疗方法不同为观察组30例和对照组30例。对照组进行常规化疗方案治疗，观察组在化疗期间再给予口服双歧杆菌乳杆菌三联活菌片（金双歧），化疗当天服用，每次2片，每天3次，4周为1个疗程，化疗前后进行肠道菌群检测（肠杆菌、肠球菌、双歧杆菌、乳酸杆菌、大肠埃希菌），记录化疗后呼吸、泌尿、消化、皮肤系统感染发生情况。结果观察组治疗后双歧杆菌、乳杆菌较治疗前明显增多（t ＝3.947、3．636，均 P ＜0．05），肠杆菌、肠球菌、大肠埃希菌治疗前后差异均无统计学意义（均 P ＞0．05），对照组治疗后肠杆菌、肠球菌、双歧杆菌、乳酸杆菌、大肠埃希菌均较治疗前明显降低（t ＝3．712、3.641、3．722、3.543、3．616，均 P ＜0．05），观察组治疗后肠杆菌、肠球菌、双歧杆菌、乳酸杆菌、大肠埃希菌明显高于对照组（t ＝3．327、3．641、6．378、7．367、3．364，均 P ＜0．05）；观察组出现呼吸道感染、胆囊炎、肠炎、泌尿系统感染的发生率分别为50．00％、6．67％、16．67％、23．33％，明显低于对照组的93．33％、30．00％、63.33％、60．00％（χ2＝13．871、5．455、13．611、8．297，均 P ＜0．05）。结论小儿血液肿瘤化疗后可能造成肠道菌群失调，是引起化疗后各种感染的重要原因，微生态制剂能够重建肠道生态平衡，提高肠道益生菌数量，扶植正常菌群生长，调整肠道菌群失调，降低感染发生概率，利于化疗顺利完成，值得临床推广应用。
Objective To investigate the effect of micro ecological preparation on imbalance of intestinal flora in pediatric blood cancer after chemotherapy.Methods The clinical data of 60 patients with blood cancer were retrospectively analyzed.All patients were divided into the observation group and control group by different trentment methods,30 cases in each group.The control group were received conventional chemotherapy,the observation group were given Lactobacillus triple viable Bifidobacterium piece（two piece once,tid,4 weeks for a course）on the basis of the control group,the intestinal flora（Enterobacteriaceae,Enterococcus,Bifidobacterium,Lactobacillus,Escherichia coli）were detected before and after chemotherapy,made a record of respiratory,urinary,digestive,skin infections after chemotherapy.Results The Bifidobacterium and Lactobacillus of the observation group after treatment were signifi-cantly higher than before treatment（t =3.947,3.636,all P 〈0.05）,there were no difference in Enterobacter,Entero-coccus,Escherichia coli in the observation group before and after treatment（all P 〉;0.05）.The Enterobacter,Entero-coccus,Bifidobacterium,Lactobacillus,Escherichia coli of the control group were lower after treatment than before treatment（t =3.712,3.641,3.722,3.543,3.616,all P 〈0.05）,the Enterobacter,Enterococcus,Bifidobacterium, Lactobacillus,Escherichia coli of the observation group after treatment were higher than that of the control group（t =3.327,3.641,6.378,7.367,3.364,all P 〈0.05）.The respiratory tract infection,cholecystitis,colitis,urinary tract infections incidence of the observation group were 50.00%,6.67%,16.67%,23.33%,respectively,which were low-er than 93.33%,30.00%,63.33%,60.00% of the control group（χ2 =13.871,5.455,13.611,8.297,all P 〈0.05）.Conclusion The intestinal flora may be caused for treatment of chemotherapy,which are the importmant rea-son of various infections after chemotherapy,the Probiotics can reconstruct the ecological balance of the gut,increase the nu
出处
《中国基层医药》
CAS
2015年第10期1484-1486,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
血液肿瘤
肠杆菌科
儿童
Hematologic Neoplasms
Enterobacteriaceae
Child
