摘要
目的观察重组人B型钠尿肽(新活素)联合替罗非班治疗急性心肌梗死合并心力衰竭临床疗效。方法将纳入研究的急性心肌梗死合并心力衰竭患者随机分为观察组和对照组。观察组64例在常规西医治疗的基础上给予新活素联合替罗非班治疗,而对照组给予常规西医治疗和尿激酶。治疗48h后观察两组患者的临床疗效、心功能指标改善情况以及安全性指标。结果观察组总有效率为98.39%,明显高于对照组的82.86%,差异有统计学意义(P<0.05);治疗后两组患者心功能指标均有所改善,差异有统计学意义(P<0.05);且治疗后观察组心功能指标明显优于对照组,差异有统计学意义(P<0.05);两组均未发生严重不良反应。结论新活素联合替罗非班治疗急性心肌梗死合并心力衰竭临床疗效确切,优于传统的尿激酶治疗,值得临床推广。
Objective To observe the effect of rh-BNP combined with tirofiban for treating acute myocardial infarction combined with heart failure.Methods The patients with acute myocardial infarction combined with heart failure were randomly divided into observation group and control group.A total of 64 patients in the observ ation group were given rh-BNP combined with tirofiban for treatment on basis of routine treatment of Western medicine while patients in the control group was treated with conventional Western medicine and urokinase.The clinical efficacy,improvement of heart function index and the safety index of two groups after 48 hours of treatment in the two groups were compared.Results The total effective rate of the obse rvation group was 98.39% ,which was significant higher than 82.86% of the control group（P〈0.05）.After treatment,each index of cardiac function in two groups was improved,with significant difference before treatment（P〈0.05）.The cardiac function indexes of the observation group after treatment was significant different with that of the control group（P〈0.05）.There was no serious adverse reaction in the two groups.Conclusion The rh-BNP combined with tirofiban has a good clinical curative effect in treatment of acute myocardial infarction combined with heart failure,which is better than urokinase therapy,it is worthy of clinical promotion.
出处
《检验医学与临床》
CAS
2015年第10期1407-1408,共2页
Laboratory Medicine and Clinic
