摘要
目的 评价CT引导下射频消融治疗结直肠癌肺内孤立性转移灶的安全性、局部控制效果及生存率.方法 对28例结直肠癌肺内孤立性转移灶患者进行CT引导下射频消融治疗（射频消融组）,病灶直径1.2～5.0（2.9±1.0） cm;并将9例未采取任何治疗的结直肠癌肺内孤立性转移灶患者作为对照组,病灶直径2.0～5.0 （3.6± 1.0） cm.比较两组局部无进展率及总生存率.结果 射频消融组患者均能完成射频消融治疗,术中、术后未发生严重并发症.射频消融组1,2和3年局部无进展率和总生存率明显高于对照组（局部无进展率：89.3％比76.2％、78.6％比33.9％、70.7％比16.9％,总生存率：96.4％比77.8％、85.7％比44.4％、56.7％比22.2％）,差异有统计学意义（P＜ 0.01）.结论 CT引导下射频消融治疗结直肠癌肺内孤立性转移灶微创、安全有效,可明显提高局部无进展率及总生存率.
Objective To evaluate the safety,local efficacy and survival rates of isolated pulmonary metastases from colorectal carcinoma treated with CT-guided radiofrequency ablation.Methods A total of 28 patients with isolated pulmonary metastases from colorectal carcinoma were performed with CT-guided radiofrequency ablation （radiofrequency ablation group）.The size of the lesion was 1.2-5.0 （2.9 ± 1.0） cm.During the same time,9 patients,who did not take any treatment for isolated pulmonary metastases from colorectal carcinoma,were collected as control group.The size of the lesion was 2.0-5.0 （3.6 ± 1.0） cm.The local progression-free rates and overall survival rates were compared.Results All the cases were able to complete the radiofrequency ablation in radiofrequency ablation group.During and after the procedure,no major complications occurred.The 1-,2-,and 3-year local progression-free rates and overall survival rates in radiofrequency ablation group were significantly higher than those in control group.The local progression-free rates were 89.3% vs.76.2%,78.6% vs.33.9%,70.7% vs.16.9%.The overall survival rates were 96.4% vs.77.8%,85.7% vs.44.4%,56.7% vs.22.2%.The differences between two groups had statistical significance （P 〈 0.01）.Conclusion CT-guided radiofrequency ablation for isolated pulmonary metastasis from colorectal carcinoma is a safe,effective,minimally invasive treatment,and can significantly improve the local progression-free rates and overall survival rates.
出处
《中国医师进修杂志》
2015年第5期342-345,共4页
Chinese Journal of Postgraduates of Medicine
基金
国家自然科学青年基金（61201430）
关键词
结直肠肿瘤
肿瘤转移
导管消融术
Colorectal neoplasms
Neoplasm metastasis
Catheter ablation
