摘要
目的对安徽省174例苯丙酮尿症(phenylketonuria,PKU)患儿的智力发育情况进行分析,以了解PKU患儿智力发育水平及其相关因素。方法以安徽省妇幼保健所新生儿疾病筛查中心诊治的174例PKU患儿为研究对象,收集患儿病历中最近1次的智力测试结果、出生和治疗等相关信息,并对患儿监护人进行问卷调查。结果起始治疗月龄<3个月的PKU患儿与起始治疗月龄≥3个月的患儿发育商得分和大运动、精细动作、适应能力、语言、社交行为5个领域的得分差异均有统计学意义(均有P<0.05);多因素Logistic回归分析表明,父母亲文化程度高、家庭年收入高的患儿智力发育商得分较高;起始治疗月龄较大的PKU患儿发育商得分较低。结论早期治疗的苯丙酮尿症患儿智力发育好,家庭因素对患儿的智力发育也有重要影响。
Objective This study aims to analyze the status of mental development in 174 children with phenylke- tonuria（PKU） from Anhui province, and to identify the mental development level and related risk factors. Methods 174 PKU cases diagnosed and treated at the Anhui Provincial Center for Women and Children＇ s Heath were selected. The status of mental development was evaluated using ＂ Neuropsychological development Scales for children aged 0 to 6 ＂ developed by Capital Institute of Pediatrics. The latest intelligence test results and information containing birth and treatment status were collected from medical records. Other information was obtained from a questionnaire survey among guardians of PKU children at the same time. Results The scores of overall and five areas （ gross motor skills, fine motor skills, adaptability, language and social behavior） were significantly higher in children treated earlier before 3 months of birth than those treated later （ all P 〈 0. 05 ）. Multivariate analysis by Logistic regression showed that the children whose parents with higher education and higher family income were more likely to have higher scores, and the children who were treated later were more likely to have lower scores. Conclusions Children with PKU would have better mental development if treated early, by which home factors play important roles in their mental development as well.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2015年第5期466-469,共4页
Chinese Journal of Disease Control & Prevention
基金
安徽省卫生厅第二批科研计划(13FR008)
关键词
苯丙酮尿症
智力
儿童发育
危险因素
Phenylketonuria
Mental
Child development
Risk factors
