摘要
目的探讨精神分裂症患者食管癌根治术后复发的脑电超慢涨落图特征。方法回顾性分析1例躁狂型精神分裂症患者行食管癌根治术后复发的临床及脑超慢涨落图特征并文献复习。结果患者术前2 d脑电超慢涨落图表现:r-氨基丁酸(S1)为7Hz、乙酰胆碱受体(S3)为36Hz、5-羟色胺(S4)为26Hz、乙酰胆碱(S5)为9Hz、去甲肾上腺素(S7)为10Hz、多巴胺(S11)为4Hz;患者术后10天脑电超慢涨落图表现:r-氨基丁酸(10 Hz)、乙酰胆碱(16 Hz)、去甲肾上腺素(15 Hz)及多巴胺(5 Hz)水平较术前升高,乙酰胆碱受体(25 Hz)、5-羟色胺(22 Hz)水平降低;患者术后1个月化疗前脑电超慢涨落图表现,脑内谷氨酸(10 Hz)、多巴胺(22 Hz)水平较术前较术后10 d升高,r-氨基丁酸(8 Hz)、乙酰胆碱受体(19 Hz)、乙酰胆碱(15 Hz)水平降低;术后2个月化疗前脑电超慢涨落图表现,脑内乙酰胆碱受体(34 Hz)、5-羟色胺(27 Hz)、乙酰胆碱(17 Hz)和多巴胺(12 Hz)水平较第1次化疗前升高,谷氨酸(2 Hz)、r-氨基丁酸(1 Hz)及去甲肾上腺素(8 Hz)水平降低;术后3个月化疗前脑电超慢涨落图表现,脑内乙酰胆碱(28 Hz)、多巴胺(17 Hz)水平较第2次化疗前继续升高,去甲肾上腺素(5 Hz)水平再次降低。结论精神分裂症并发食管癌患者术后复发可导致精神疾病病情恶化;脑电超慢涨落图检查无创简便易行,可为临床动态观察并预防精神分裂症患者术后复发提供依据。
Objective To explore the clinical and encephalofluctuograph technology （ET） characteristics for patients with schizophrenia recurrence complicated with esophageal cancer.Methods Clinical and ET characteristics of one case of merger mania schizophrenia relapsed patient with esophageal cancer after esophageal resection were retrospectively analyzed, and the literatures were reviewed. Results Two days before the operation, r-aminobutyric acid （ S1 ） , acetylcholine receptor （ S3 ） , 5-HT （ S4）, acetylcholine （ S5 ）, norepinephrine （S7 ）, dopamine （ S11 ） were 7Hz, 36Hz, 26Hz, 9Hz, 10Hz, 4Hz respectively in ET. Compared with preoperation, the value of r-aminobutyric acid, acetylcholine, norepinephrine, dopamine increased in ET ten days after the operation while the value of acetylcholine receptor, 5-HT decreased.The value of glutamic acid and dopamine increased in ET a month after the operation, while r-aminobutyric acid, acetylcholine receptor, acetylcholine decreased compared with those in ET ten days after operation.After the operation, the value of neurotransmitters in ET two months after the operation showed that acetylcholine receptor, 5-HT, acetylcholine and dopamine increased, while glutamic acid, r-aminobntyric acid and norepinephrine decreased. The value of acetylcholine and dopamine in ET at three months after the operation increased compared with those in ET at two months after the operation, while norepinephrine decreased.Conclusions The schizophrenia recurrence leads to deterioration of mental illness.ET is noninvasive and simple and it can provide evidence of clinical dynamic observation and prevent recurrence in patients with schizophrenia.
出处
《中华诊断学电子杂志》
2015年第1期22-24,共3页
Chinese Journal of Diagnostics(Electronic Edition)
基金
全军医药卫生科研基金项目(08G018)
关键词
食管肿瘤
精神分裂症
脑电超慢涨落图
Esophageal neoplasms
Schizophrenia
Encephalofluctuograph technology
