摘要
目的探讨连环蛋白（beta-catenin）在胆管细胞癌中的表达特点及其临床意义。方法检测70例胆管细胞癌组织标本中beta-catenin的表达水平，并与患者临床、病理参数的相关性进行分析。结果Beta-catenin在正常胆管组织及癌旁组织阳性表达率分别为6．67％（1／15）、9．09％（3／33）。beta-catenin在胆管细胞癌中阳性表达率为57．14％，显著高于正常胆管组织和癌旁组织（P〈0.05）。胆管细胞癌分化程度越高，beta-catenin的阳性表达率越高，高分化组与低分化组比较差异有统计学意义（P〈0．05）。beta-catenin的表达与患者年龄和淋巴结转移有明显相关性，年龄越大患者阳性表达率越高，有淋巴结转移组与无淋巴结转移组比较差异有统计学意义（P〈0．05）。结论Beta-catenin的表达程度随肿瘤分化程度的增高而逐渐增强，beta-catenin可能参与肿瘤的浸润及转移，表达程度受年龄、有无淋巴结转移等病理参数影响。
Objective To explore the expression and significance of beta-catenin in cholangiocarcinoma. Methods To detect the expression of beta-eatenin in 70 cases of samples with cholangiocar cinoma. The relationship between beta-eatenin and clinical pathologic parameters was analyzed. Results The positive rate of beta-catenin in normal bile duct and adjacent tissues was 6.67% （ 1/15 ） and 9.09% （ 3/33 ） respectively. The positive rate of beta-catenin in cholangiocarcinoma was 57.14% and it was significantly higher than normal bile duct and adjacent tissues （ P〈0.05 ） .The positive rate increased with the developing process of cancer. The high differentiation was higher than poorly differentiated. The expression of beta-catenin had a significantly positive correlation with and clinical pathologic parameters （ P〈0.05 ） .The positive expression rate of beta-catenin was higher in older patients. The positive expression rate of lymph node metastasis group was significantly greater than the without group （ P〈0.05 ） . Conclusion The expression of beta - catenin increases with the developing of tumor differentiation. The beta-catenin may take part in the tumor invasion and metastasis. The expression of beta-catenin has correlation with the pathological parameters, such as age and lymph node metastasis.
出处
《浙江临床医学》
2015年第5期702-704,共3页
Zhejiang Clinical Medical Journal
基金
浙江省温州市科技局基金项目（Y20120043）
关键词
胆管细胞癌
连环蛋白
病理参数
Cholangiocarcinoma
Beta-catenin
Clinical pathologic parameters
